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Effect of weight loss on adipokine levels in obese patients.

Rolland, Catherine; Hession, Michelle; Broom, Iain


Catherine Rolland

Michelle Hession

Iain Broom


Adipose tissue functions as an endocrine organ by releasing adipokines, which have important roles in the regulation of inflammation and insulin sensitivity. Although there is evidence of improvements in the circulating levels of adipokines with weight loss, few studies relate such changes to specific diets. We investigated the effect of weight loss achieved by two different diets on circulating adipokine levels in obese individuals. 120 obese patients (BMI greater than or equal to 35 kg/m2) underwent a screening period of three months on a low-fat, reduced-calorie diet. Patients who failed to achieve a 5% weight loss using this approach were randomly allocated to either a low-carbohydrate/high-protein diet (LCHP) (n=17) or to a commercial very-low-calorie diet (LighterLife / "LL") (n=14) for a period of nine months. Significant weight loss was maintained only for LL at nine months (-32.3 ± 22.7, p < 0.0001), not LCHP. Changes in adiponectin (ng/ml) (15.8 ± 17.1 vs -0.8 ± 6.2, p = 0.003) and leptin (ng/ml) (-17.6 ± 24.3 vs -3.0 ± 9.2, p = 0.049) at nine months were significantly greater for LL than for LCHP, which may reflect greater weight loss and decrease in fat mass. Changes in TNF-alpha, IL-6 and PAI-1 did not differ significantly between the dietary interventions at nine months. In conclusion, a significant weight loss of 23.8% of baseline weight was observed using a very-low-calorie diet, and resulted in significant improvements in circulating levels of leptin, PAI-1 and adiponectin. These results are likely due to the weight loss and not the macronutrient intake.


ROLLAND, C., HESSION, M. and BROOM, I. 2011. Effect of weight loss on adipokine levels in obese patients. Diabetes, metabolic syndrome and obesity: targets and therapy [online], 4, pages 315-323. Available from:

Journal Article Type Article
Acceptance Date Aug 3, 2011
Online Publication Date Aug 3, 2011
Publication Date Aug 31, 2011
Deposit Date Sep 5, 2012
Publicly Available Date Sep 5, 2012
Journal Diabetes, metabolic syndrome and obesity: targets and therapy
Electronic ISSN 1178-7007
Publisher Dove Medical Press
Peer Reviewed Peer Reviewed
Volume 4
Pages 315-323
Keywords Weight loss; Adipokine; Obesity
Public URL


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