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Very-low-energy diets and morbidity: a systematic review of longer-term evidence.

Mulholland, Y.; Nicokavoura, E.; Broom, J.; Rolland, C.


Y. Mulholland

E. Nicokavoura

J. Broom

C. Rolland


Evidence from the literature supports the safe use of very-low-energy diets (VLED) for up to 3 months in supervised conditions for patients who fail to meet a target weight loss using a standard low-fat, reduced-energy approach. There is, however, a need for longer-term outcomes on obesity and associated morbidities following a VLED. The present systematic review aims to investigate longer-term outcomes from studies using VLED, with a minimum duration of 12 months, published between January 2000 and December 2010. Studies conducted in both children and adults, with a mean/median BMI of ≥ 28 kg/m2 were included. PubMed, MEDLINE, Web of Science and Science Direct were searched. Reference lists of studies and reviews were manually searched. Weight loss or prevention of weight gain and morbidities were the main outcomes assessed. A total of thirty-two out of 894 articles met the inclusion criteria. The duration of the studies ranged from 12 months to 5 years. Periods of VLED ranged from 25 d to 9 months. Several studies incorporated aspects of behaviour therapy, exercise, low-fat diets, low-carbohydrate diets or medication. Current evidence demonstrates significant weight loss and improvements in blood pressure, waist circumference and lipid profile in the longer term following a VLED. Interpretation of the results, however, was restricted and conclusions with which to guide best practice are limited due to heterogeneity between the studies. The present review clearly identifies the need for more evidence and standardised studies to assess the longer-term benefits from weight loss achieved using VLED.


MULHOLLAND, Y., NICOKAVOURA, E., BROOM, J. and ROLLAND, C. 2012. Very-low-energy diets and morbidity: a systematic review of longer-term evidence. British journal of nutrition [online], 108(5), pages 832-851. Available from:

Journal Article Type Article
Acceptance Date Jul 17, 2012
Online Publication Date Jul 17, 2012
Publication Date Sep 14, 2012
Deposit Date Dec 5, 2012
Publicly Available Date Dec 5, 2012
Journal British journal of nutrition
Print ISSN 0007-1145
Electronic ISSN 1475-2662
Publisher Cambridge University Press (CUP)
Peer Reviewed Peer Reviewed
Volume 108
Issue 5
Pages 832-851
Keywords Obesity; Systematic reviews; Very low energy diets; Morbidity
Public URL


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