Iain Broom
Thinking around abdominal obesity and cardiovascular risk.
Broom, Iain
Authors
Abstract
Obesity, particularly intra-abdominal (visceral) obesity, is a leading cause of cardiovascular disease (CVD), insulin resistance, type 2 diabetes, dyslipidaemia, inflammation and thrombosis. A useful indicator for visceral fat is waist circumference, which is associated with all-cause mortality. Pro-inflammatory adipokines play a causal role in the development of pathologies associated with insulin resistance, type 2 diabetes and CVD. In addition to established anti-obesity therapies, namely orlistat and sibutramine, a new type of agent that inhibits the cannabinoid receptor (CB1) is advanced in development to reduce appetite and act predominantly against intra-abdominal adiposity.
Citation
BROOM, I. 2006. Thinking around abdominal obesity and cardiovascular risk. British journal of diabetes and vascular disease, 6(2), pages 58-61.
Journal Article Type | Article |
---|---|
Acceptance Date | Mar 31, 2006 |
Online Publication Date | Mar 31, 2006 |
Publication Date | Mar 31, 2006 |
Deposit Date | Dec 6, 2012 |
Publicly Available Date | Dec 6, 2012 |
Journal | British journal of diabetes and vascular disease |
Print ISSN | 1474-6514 |
Electronic ISSN | 1753-4305 |
Publisher | SAGE Publications |
Peer Reviewed | Peer Reviewed |
Volume | 6 |
Issue | 2 |
Pages | 58-61 |
DOI | https://doi.org/10.1177/14746514060060020301 |
Keywords | Abdominal obesity; Metabolic syndrome; Visceral fat; Waist circumference; Cardiometabolic risk |
Public URL | http://hdl.handle.net/10059/783 |
Contract Date | Dec 6, 2012 |
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https://creativecommons.org/licenses/by-nc-nd/4.0/
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