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The effect of very low-calorie diets on renal and hepatic outcomes: a systematic review.

Rolland, Catherine; Mavroeidi, Alexandra; Johnston, Kelly L.; Broom, John

Authors

Catherine Rolland

Alexandra Mavroeidi

Kelly L. Johnston

John Broom



Abstract

Very low-calorie diets (VLCDs) are an effective means by which to induce clinically significant weight loss. However, their acceptance by health care practitioners and the public is generally lower than that for other nonsurgical weight loss methods. Whilst there is currently little evidence to suggest they have any detrimental effect on hepatic and renal health, data assessing these factors remain limited. We carried out a systematic review of the literature on randomized controlled trials that had a VLCD component and that reported outcomes for hepatic and renal health, published between January 1980 and December 2012. Cochrane criteria were followed, and eight out of 196 potential articles met the inclusion criteria. A total of 548 participants were recruited across the eight studies. All eight studies reported significant weight loss following the VLCD. Changes in hepatic and renal outcomes were variable but generally led to either no change or improvements in either of these. Due to the heterogeneity in the quality and methodology of the studies included, the effect of VLCDs on hepatic and renal outcomes remains unclear at this stage. Further standardized research is therefore required to fully assess the impact of VLCDs on these outcome measures, to better guide clinical practice.

Citation

ROLLAND, C., MAVROEIDI, A., JOHNSTON, K.L. and BROOM, J. 2013. The effect of very low-calorie diets on renal and hepatic outcomes: a systematic review. Diabetes, metabolic syndrome and obesity: targets and therapy [online], 6, pages 393-401. Available from: https://doi.org/10.2147/DMSO.S51151

Journal Article Type Review
Acceptance Date Aug 6, 2013
Online Publication Date Oct 11, 2013
Publication Date Dec 31, 2013
Deposit Date Nov 6, 2013
Publicly Available Date Nov 6, 2013
Journal Diabetes, metabolic syndrome and obesity: targets and therapy
Print ISSN 1178-7007
Electronic ISSN 1178-7007
Publisher Dove Medical Press
Peer Reviewed Peer Reviewed
Volume 6
Pages 393-401
DOI https://doi.org/10.2147/DMSO.S51151
Keywords Obesity; Systematic review; Liver; Kidney; Weight loss; Health very low calorie diet
Public URL http://hdl.handle.net/10059/894

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