Global cancer nurse's experiences and perceptions of potential occupational exposure to cytotoxic drugs: mixed methods systematic review with framework synthesis.

Campbell, Karen; Afseth, Janyne; Dunham, Margaret; King, Maria; Dicksit, Daniel

Abstract

To conceptualise experiences and perceptions of cancer nurses' potential for occupational exposure when dealing with cytotoxic drugs (CDs). A mixed methods systematic review with framework synthesis. A literature search was conducted in February 2022 in CINAHL PubMed, Web of Science, Ovid Nursing, and PsycINFO, and it was reported using the PRISMA guidance. A synthesis of 38 studies revealed new categories of perceived solutions, side effects, and risky behaviour as well as three levels of experience and perception: individual, shared, and cultural, rather than the a priori theory. The review conclude that individuals espouse safe handling and administration of CDs. Synthesis highlights a complex interplay between self-reported perception and the observed experience of potential occupational exposure to cytotoxic drugs. The framework synthesis highlights the difference between the perception of espoused practice and the experience of practice. Observation and risk assessment must be used to enhance safe practice. Organisations must take seriously the perception and experience of the adverse effects of administering cytotoxic drugs to support cancer nurses. Joanna Briggs Institute's (JBI) methodology for systematic reviews and framework synthesis indexed studies deductively and inductively. Trial Registration: PROSPERO: CRD42022289276.

Citation

CAMPBELL, K., AFSETH, J., DUNHAM, M., KING, M. and DICKSIT, D. 2024. Global cancer nurse's experiences and perceptions of potential occupational exposure to cytotoxic drugs: mixed methods systematic review with framework synthesis. Journal of clinical nursing [online], 33(12), pages 4585-4601. Available from: https://doi.org/10.1111/jocn.17488

• Journal Article Type: Article
• Acceptance Date: Sep 27, 2024
• Online Publication Date: Oct 29, 2024
• Publication Date: Dec 31, 2024
• Deposit Date: Oct 1, 2024
• Publicly Available Date: Oct 29, 2024
• Journal: Journal of clinical nursing
• Print ISSN: 0962-1067
• Electronic ISSN: 1365-2702
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 33
• Issue: 12
• Pages: 4585-4601
• DOI: https://doi.org/10.1111/jocn.17488
• Keywords: Cancer nurses; Cytotoxic drugs; Occupational exposure to cytotoxic drugs; Systematic review; Safe handling
• Public URL: https://rgu-repository.worktribe.com/output/2508890
• Related Public URLs: https://rgu-repository.worktribe.com/output/2548299 (PROSPERO Protocol)
• Additional Information: This article has been published with separate supporting information. This supporting information has been incorporated into a single file on this repository and can be found at the end of the file associated with this output.