SSRI antidepressants and perceived loss of lean muscle in men: a qualitative exploration of some online anecdotal concerns.

Adams, Nicholas Norman

Abstract

This study examines anecdotal reports from online discussion forums suggesting possible links between SSRI antidepressants and loss of lean muscle mass, particularly in men. Given limited existing scientific research, this study bolsters academic discourse. The specific research question was, "Do self-reported experiences from internet forums indicate a perceived connection between SSRI use and muscle mass reductions?". A Google keyword search identified 202 posts from 14 randomly selected online antidepressant discussion forums. Posts were collected and thematically analysed. Forum users reported difficulties in maintaining or gaining lean muscle after commencing SSRI treatment. Key themes included frustration, confusion, and attempts to rationalise perceived changes. Findings suggest an area for further exploration, regarding the physiological impact of SSRIs on muscle composition. While reports remain anecdotal, they highlight concerns immediately relevant to both patients and healthcare professionals. As the study is based on self-reported experiences from anonymous sources, findings lack scientific validation, but highlight requirements for further studies to explore prevalence and broader applicability. Research observations spotlight a need for further, structured clinical research to investigate possible effects of SSRIs on muscle mass. Future research should include controlled clinical trials and longitudinal studies to examine a potential association in more detail.

Citation

ADAMS, N.N. [2025]. SSRI antidepressants and perceived loss of lean muscle in men: a qualitative exploration of some online anecdotal concerns. International journal of risk and safety in medicine [online], OnlineFirst. Available from: https://doi.org/10.1177/09246479251346445

• Journal Article Type: Article
• Acceptance Date: May 13, 2025
• Online Publication Date: May 23, 2025
• Deposit Date: May 23, 2025
• Publicly Available Date: May 23, 2025
• Journal: International journal of risk and safety in medicine
• Print ISSN: 0924-6479
• Publisher: IOS Press
• Peer Reviewed: Peer Reviewed
• DOI: https://doi.org/10.1177/09246479251346445
• Keywords: Selective serotonin re-uptake inhibitors (SSRIs); Antidepressants; Drug side-effects; Lean muscle loss; Social pharmacy
• Public URL: https://rgu-repository.worktribe.com/output/2842697