Single-atom nanozymes for electrochemical sensing oxidative stress biomarkers.

Mani, Veerappan; Tostado-Blazquez, Guillermo; Ramalingam, Vinoth; Salama, Khaled Nabil

Abstract

Developing reliable and low-cost sensors for oxidative stress biomarkers has gained significant interest for understanding and managing chronic diseases. Recently, single-atom nanozymes (SANs) with atomically dispersed metal sites and unique metal–nitrogen–carbon (M–N–C) structures have emerged as promising redox enzyme mimetics, offering superior catalytic efficiency and specificity, and with exceptional sensing capabilities for oxidative stress biomarkers such as hydrogen peroxide (H2O2), nitric oxide (NO), glutathione (GSH), and uric acid (UA). This review discusses key progress, challenges, and future directions in SANs for electrochemical determination of oxidative stress biomarkers, aiming to guide future research toward practical and impactful solutions in healthcare and disease management.

Citation

MANI, V., TOSTADO-BLAZQUEZ, G., RAMALINGAM, V. and SALAMA, K.N. 2025. Single-atom nanozymes for electrochemical sensing oxidative stress biomarkers. Trends in chemistry [online], In Press. Available from: https://doi.org/10.1016/j.trechm.2025.04.008

• Journal Article Type: Article
• Acceptance Date: May 20, 2025
• Online Publication Date: May 20, 2025
• Deposit Date: May 23, 2025
• Publicly Available Date: May 21, 2026
• Journal: Trends in chemistry
• Print ISSN: 2589-7209
• Electronic ISSN: 2589-5974
• Publisher: Cell Press
• Peer Reviewed: Peer Reviewed
• DOI: https://doi.org/10.1016/j.trechm.2025.04.008
• Keywords: Single-atom catalysts; Sensors; Biosensors; Oxidative stress markers; 2D materials
• Public URL: https://rgu-repository.worktribe.com/output/2842904