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Perinatal factors associate with vertebral size and shape but not lumbar lordosis in 10-year-old children.

Pavlova, Anastasia V.; Jeffrey, Janet E.; Barr, Rebecca J.; Aspden, Richard M.

Authors

Janet E. Jeffrey

Rebecca J. Barr

Richard M. Aspden



Abstract

The intrauterine environment is known to influence foetal development and future health. Low birthweight has been linked to smaller vertebral canals in children and decreased adulthood spine bone mineral content. Perinatal factors affecting lumbar spine curvature have not yet been considered but could be important for adult spinal health, as lumbar movement during lifting, a risk factor for backpain, is associated with lordosis. To investigate this, lumbar spine magnetic resonance images at age 10 years and perinatal and maternal data (birthweight, placental weight, gestation length, crown-heel length, maternal age, height, weight and smoking status) from 161 children born in Aberdeen in 1988–1989 were acquired. Statistical shape modelling, using principal component analysis, quantified variations in lumbar spine shape and resulting modes of variation were assessed in combination with perinatal data using correlations and analyses of covariance, adjusted for potential confounders. Spine modes 1–3 (SM1–SM3) captured 75% of the variation in lumbar spine shape. The first and third modes described the total amount (SM1) and evenness of curvature distribution (SM3). SM2 accounted for variations in antero-posterior vertebral diameter relative to vertebral height, increasing positive scores representing a larger relative diameter. Adjusting for gestation length and sex, SM2 positively correlated with birthweight (r = 0.25, P < 0.01), placental weight (r = 0.20, P = 0.04), crown-heel length (r = 0.36, P < 0.001) and maternal weight (r = 0.19, P = 0.04), and negatively with maternal age (r = -0.22, P = 0.02). SM2 scores were lower in girls (P < 0.001) and in the low birthweight group (P = 0.02). There were no significant differences in SM1 and SM3 scores between birthweight groups, boys and girls or children of smokers (31%) and non-smokers (69%). In conclusion, some perinatal factors were associated with vertebral body morphology but had little effect on lumbar curvature.

Citation

PAVLOVA, A.V., JEFFREY, J.E., BARR, R.J. and ASPDEN, R.M. 2019. Perinatal factors associate with vertebral size and shape but not lumbar lordosis in 10-year-old children. Journal of anatomy [online], 235(4), pages 749-756. Available from: https://doi.org/10.1111/joa.13024

Journal Article Type Article
Acceptance Date May 3, 2019
Online Publication Date Jun 20, 2019
Publication Date Oct 31, 2019
Deposit Date Jul 22, 2019
Publicly Available Date Jun 21, 2020
Journal Journal of Anatomy
Print ISSN 0021-8782
Electronic ISSN 1469-7580
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 235
Issue 4
Pages 749-756
DOI https://doi.org/10.1111/joa.13024
Keywords Lumbar spine; Perinatal factors; Antenatal; Lordosis; Statistical shape modelling
Public URL https://rgu-repository.worktribe.com/output/321726

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