Stella G. Muthuri
Associations between back pain across adulthood and spine shape in early old age in a British birth cohort.
Muthuri, Stella G.; Pavlova, Anastasia V.; Saunders, Fiona R.; Hardy, Rebecca J.; Gregory, Jennifer S.; Barr, Rebecca J.; Martin, Kathryn R.; Adams, Judith E.; Kuh, Diana; Aspden, Richard M.; Cooper, Rachel
Authors
Dr Anastasia Pavlova a.pavlova1@rgu.ac.uk
Research Fellow
Fiona R. Saunders
Rebecca J. Hardy
Jennifer S. Gregory
Rebecca J. Barr
Kathryn R. Martin
Judith E. Adams
Diana Kuh
Richard M. Aspden
Rachel Cooper
Abstract
We aimed to examine whether back pain across adulthood was associated with spine shape at age 60–64 years. Data were from 1405 participants in the MRC National Survey of Health and Development, a nationally representative British birth cohort. Back pain was ascertained during nurse interviews at ages 36, 43, 53 and 60–64 years. Cumulative exposure to back pain was then derived by counting the number of ages at which back pain was reported. Statistical shape modelling was used to characterise thoracolumbar spine shape using lateral dual-energy x-ray absorptiometry images which were ascertained at age 60–64 years. Linear regression models were used to test associations of spine shape modes (SM) with: (1) cumulative exposure to back pain; (2) back pain reports during different periods of adulthood. After adjusting for sex, higher cumulative exposure to back pain across adulthood was associated with wedge-shaped L4-5 disc (lower SM4 scores) and smaller disc spaces (higher SM8 scores) in both sexes. In addition, reporting of back pain at ages 53 and/or 60–64 years was associated with smaller L4-5 disc space (lower SM6 scores) in men but not women. These findings suggest that back pain across adulthood may be associated with specific variations in spine shapes in early old age.
Citation
MUTHURI, S.G., PAVLOVA, A.V., SAUNDERS, F.R., HARDY, R.J., GREGORY, J.S., BARR, R.J., MARTIN, K.R., ADAMS, J.E., KUH, D., ASPDEN, R.M. and COOPER, R. 2018. Associations between back pain across adulthood and spine shape in early old age in a British birth cohort. Scientific reports [online], 8, article ID 16309. Available from: https://doi.org/10.1038/s41598-018-34628-9
Journal Article Type | Article |
---|---|
Acceptance Date | Oct 22, 2018 |
Online Publication Date | Nov 5, 2018 |
Publication Date | Dec 31, 2018 |
Deposit Date | Sep 19, 2019 |
Publicly Available Date | Sep 19, 2019 |
Journal | Scientific Reports |
Electronic ISSN | 2045-2322 |
Publisher | Springer |
Peer Reviewed | Peer Reviewed |
Volume | 8 |
Article Number | 16309 |
DOI | https://doi.org/10.1038/s41598-018-34628-9 |
Keywords | Back pain; Disability; Adulthood; Spine shape; Shape modelling; Thoracolumbar spine shape |
Public URL | https://doi.org/10.1038/s41598-018-34628-9 |
Files
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Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
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