Statistical shape modelling of hip and lumbar spine morphology and their relationship in the MRC National Survey of Health and Development.

Pavlova, Anastasia V.; Saunders, Fiona R.; Muthuri, Stella G.; Gregory, Jennifer S.; Barr, Rebecca J.; Martin, Kathryn R.; Hardy, Rebecca J.; Cooper, Rachel; Adams, Judith E.; Kuh, Diana; Aspden, Richard M.

Abstract

The anatomical shape of bones and joints is important for their proper function, but quantifying this and detecting pathological variations is difficult to do. Numerical descriptions would also enable correlations between joint shapes to be explored. Statistical shape modelling (SSM) is a method of image analysis employing pattern recognition statistics to describe and quantify such shapes from images. It uses principal components analysis to generate modes of variation, describing each image in terms of a set of numerical scores after removing global size variation. We used SSM to quantify the shapes of the hip and the lumbar spine in dual-energy x-ray absorptiometry (DXA) images, from 1,511 individuals in the MRC National Survey of Health and Development at ages 60–64 years. We compared shapes of both joints in men and women, and hypothesised that hip and spine shape would be strongly correlated. We also investigated associations with height, weight, body mass index (BMI) and local (hip or lumbar spine) bone mineral density. In the hip, all except one of the first ten modes differed between men and women. Men had a wider femoral neck, smaller neck-shaft angle, increased presence of osteophytes and a loss of the femoral head/neck curvature compared with women. Women presented with a flattening of the femoral head and greater acetabular coverage of the femoral head. Greater weight was associated with a shorter, wider femoral neck and larger greater and lesser trochanters. Taller height was accompanied by a flattening of the curve between superior head and neck and a larger lesser trochanter. Four of the first eight modes describing lumbar spine shape differed between men and women. Women tended to have a more lordotic spine than men, with relatively smaller but caudally increasing anterior-posterior (a-p) vertebral diameters. Men were more likely to have a straighter spine with larger vertebral a-p diameters relative to vertebral height than women, increasing cranially. A weak correlation was found between body weight and a-p vertebral diameter. No correlations were found between shape modes and height in men, whereas in women there was a weak positive correlation between height and evenness of spinal curvature. Linear relationships between hip and spine shapes were weak and inconsistent in both sexes, thereby offering little support for our hypothesis. In conclusion, men and women entering their seventh decade have small but statistically significant differences in the shapes of their hips and their spines. Associations with height, weight, BMI and BMD are small, and correspond to subtle variations whose anatomical significance is not yet clear. Correlations between hip and spine shapes are small.

Citation

PAVLOVA, A.V., SAUNDERS, F.R., MUTHURI, S.G., GREGORY, J.S., BARR, R.J., MARTIN, K.R., HARDY, R.J., COOPER, R., ADAMS, J.E., KUH, D. and ASPDEN, R.M. 2017. Statistical shape modelling of hip and lumbar spine morphology and their relationship in the MRC National Survey of Health and Development. Journal of anatomy [online], 231(2), pages 248-259. Available from: https://doi.org/10.1111/joa.12631

• Journal Article Type: Article
• Acceptance Date: Apr 4, 2017
• Online Publication Date: May 31, 2017
• Publication Date: Aug 31, 2017
• Deposit Date: Dec 16, 2019
• Publicly Available Date: Dec 16, 2019
• Journal: Journal of anatomy
• Print ISSN: 0021-8782
• Electronic ISSN: 1469-7580
• Publisher: Wiley Open Access
• Peer Reviewed: Peer Reviewed
• Volume: 231
• Issue: 2
• Pages: 248-259
• DOI: https://doi.org/10.1111/joa.12631
• Keywords: Spine; Lumbar spine; Hip; Aging; Statistical shape modelling; Image analysis
• Public URL: https://rgu-repository.worktribe.com/output/815833