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Neuropathic pain in the general population: a systematic review of epidemiological studies.

van Hecke, O.; Austin, Sophie K.; Khan, Rafi A.; Smith, B. H.; Torrance, N.


O. van Hecke

Sophie K. Austin

Rafi A. Khan

B. H. Smith


Most patients with neuropathic pain symptoms present and are managed in primary care, with only a minority being referred for specialist clinical assessment and diagnoses. Previous reviews have focused mainly on specific neuropathic pain conditions based in specialist settings. This is the first systematic review of epidemiological studies of neuropathic pain in the general population. Electronic databases were searched from January 1966 to December 2012, and studies were included where the main focus was on neuropathic pain prevalence and/or incidence, either as part of a specific neuropathic pain-related condition or as a global entity in the general population. We excluded studies in which data were extracted from pain or other specialist clinics or focusing on specific population subgroups. Twenty-one articles were identified and underwent quality assessment and data extraction. Included studies differed in 3 main ways: method of data retrieval, case ascertainment tool used, and presentation of prevalence/incidence rates. This heterogeneity precluded any meta-analysis. We categorised comparable incidence and prevalence rates into 2 main subgroups: (1) chronic pain with neuropathic characteristics (range 3–17%), and (2) neuropathic pain associated with a specific condition, including postherpetic neuralgia (3.9–42.0/100,000 person–years [PY]), trigeminal neuralgia (12.6–28.9/100,000 PY), painful diabetic peripheral neuropathy (15.3–72.3/100,000 PY), glossopharyngeal neuralgia (0.2–0.4/100,000 PY). These differences highlight the importance of a standardised approach for identifying neuropathic pain in future epidemiological studies. A best estimate of population prevalence of pain with neuropathic characteristics is likely to lie between 6.9% and 10%.


VAN HECKE, O., AUSTIN, S.K., KHAN, R.A., SMITH, B.H. and TORRANCE, N. 2014. Neuropathic pain in the general population: a systematic review of epidemiological studies. Pain [online], 155(4), pages 654-662. Available from:

Journal Article Type Review
Acceptance Date Nov 19, 2013
Online Publication Date Nov 26, 2013
Publication Date Apr 30, 2014
Deposit Date May 22, 2020
Publicly Available Date May 22, 2020
Journal Pain
Print ISSN 0304-3959
Electronic ISSN 1872-6623
Publisher Lippincott, Williams & Wilkins
Peer Reviewed Peer Reviewed
Volume 155
Issue 4
Pages 654-662
Keywords Epidemiology; Incidence; Neuropathic pain; Prevalence; Systematic review
Public URL