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HAART therapy in Ghana: comparative assessment of the effectiveness of different HAART combinations at Komfo Anokye teaching hospital.

Gyamfi, Paa Kofi Tawiah Adu; Mensah, Kwesi Boadu; Arhin, Stephen Mensah; Moomin, Aliu


Paa Kofi Tawiah Adu Gyamfi

Kwesi Boadu Mensah

Stephen Mensah Arhin


Objective: Although all marketed antiretrovirals (ARVs) have proven efficacy, genetic differences can result in varied effectiveness. This study was conducted to determine the effectiveness of different Highly Active Antiretroviral Therapy (HAART) combinations among patients attending HIV clinic at a Major Teaching Hospital in Ghana. Methods: The study was a retrospective study involving 500 patients at an HIV clinic in the Ashanti Region of Ghana. Results: Twelve major antiretroviral combinations for HAART were prescribed at the study center. The most prescribed drug combinations were AZT+3TC+EFV and AZT+3TC+NVP. The study identified that HAART, irrespective of the kind of drug combination used, was effective at increasing CD4 count within the first 6 mo of therapy initiation in the study population. However, the magnitude of the increases differed from combination to combination. All HAART combinations with zidovudine as one of the drugs resulted in higher CD4 counts compared with combinations containing stavudine. HAART with nevirapine also resulted in a higher CD4 count than those with efavirenz. However, efavirenz-based combinations appeared to be more effective in critically ill patients and patients with mean CD4+T helper cells count below 100 cell/mm3. More importantly, efavirenz was common among all HAART combinations that resulted in treatment failure. Conclusion: There was significant variation in response to different HAART combination among Ghanaian HIV patients. However, there was no statistically significant difference in mean CD4 count between the two most predominately used HAART i.e. AZT+3TC+EFV and AZT+3TC+NVP.


GYAMFI, P. K. T. A., MENSAH, K.B., ARHIN, S.M. and MOOMIN, A. 2020. HAART therapy in Ghana: comparative assessment of the effectiveness of different HAART combinations at Komfo Anokye teaching hospital. International journal of pharmacy and pharmaceutical sciences [online], 12(3), pages 89-93. Available from:

Journal Article Type Article
Acceptance Date Jan 30, 2020
Online Publication Date Feb 6, 2020
Publication Date Feb 29, 2020
Deposit Date Jun 1, 2020
Publicly Available Date Jun 1, 2020
Journal International journal of pharmacy and pharmaceutical Sciences
Print ISSN 0975-1491
Electronic ISSN 2656-0097
Peer Reviewed Peer Reviewed
Volume 12
Issue 3
Pages 89-93
Keywords Haart; AIDS; HIV; Antiretrovirals; Effectiveness; Sub-Sahara Africa
Public URL


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