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The effect of carnosine or β-alanine supplementation on markers of glycaemic control and insulin resistance in human and animal studies: a protocol for a systematic review and meta-analysis. [Protocol]

Matthews, Joseph J.; Dolan, Eimear; Swinton, Paul A.; Santos, Livia; Artioli, Guilherme G.; Turner, Mark D.; Elliott-Sale, Kirsty J.; Sale, Craig

Authors

Joseph J. Matthews

Eimear Dolan

Livia Santos

Guilherme G. Artioli

Mark D. Turner

Kirsty J. Elliott-Sale

Craig Sale



Abstract

Background: Diabetes is a major public health issue and there is a need to develop low-cost, novel interventions to prevent or reduce disease progression. Growing evidence shows that supplementation with carnosine, or its rate-limiting precursor β-alanine, can ameliorate aspects of the metabolic dysregulation that occurs in diabetes. There is, however, a need to develop a better understanding of the magnitude of effect and the factors associated with positive outcomes. The purpose of this systematic review and meta-analysis is to evaluate the effect of carnosine or β-alanine supplementation on markers of glycaemic control and insulin resistance in humans and animals. Methods: We will perform a systematic search for randomised and non-randomised controlled trials. Studies will be retrieved by searching electronic databases, clinical trial registers, author review, and cross-referencing. Primary outcomes include changes in: 1) fasting glucose; 2) glycated haemoglobin; and 3) 2-hour glucose following a glucose tolerance test. A set of additional outcomes includes other markers of glycaemic control and insulin resistance. Risk of bias (RoB) will be assessed using the Cochrane RoB 2.0 tool (human studies) and the Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) RoB tool (animal studies). Confidence in the cumulative evidence will be assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. All meta-analyses will be conducted within a Bayesian framework, providing a flexible modelling approach to account for uncertainty in model parameters and underlying structures within the data. Discussion: By including all available human and animal data, we will provide the most comprehensive overview on the topic to date. The results will have implications for those working in prediabetes, diabetes, and metabolic health in general; and may lead to the development of new treatment approaches. Dissemination: Study results will be presented at a professional conference and published in a peer-reviewed journal. Registration: CRD42020191588

Citation

MATTHEWS, J.J., DOLAN, E., SWINTON, P.A., SANTOS, L., ARTIOLI, G.G., TURNER, M.D., ELLIOTT-SALE, K.J. and SALE, C. 2020. The effect of carnosine or β-alanine supplementation on markers of glycaemic control and insulin resistance in human and animal studies: a protocol for a systematic review and meta-analysis. [Protocol]. Systematic reviews [online], 9, article ID 282. Available from: https://doi.org/10.1186/s13643-020-01539-8

Other Type Experiment
Acceptance Date Nov 19, 2020
Online Publication Date Dec 5, 2020
Publication Date Dec 31, 2020
Deposit Date Nov 23, 2020
Publicly Available Date Nov 23, 2020
Publisher Springer Verlag
DOI https://doi.org/10.1186/s13643-020-01539-8
Keywords Diabetes; Prediabetes; Metabolic health; Glucose; Therapeutics; Nutrition
Public URL https://rgu-repository.worktribe.com/output/999672
Additional Information The systematic review registration on PROSPERO is available from https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020191588

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