All Outputs (20)

Genome-guided bioprospecting for novel antibiotic lead compounds. (2023)
Thesis
AWOLOPE, O.K. 2023. Genome-guided bioprospecting for novel antibiotic lead compounds. Robert Gordon University, PhD thesis. Hosted on OpenAIR [online]. Available from: https://doi.org/10.48526/rgu-wt-1987833

Antimicrobial resistance continues to pose a threat to health and wellbeing. Unmitigated, it is predicted to be the leading cause of death by 2050. Hence, the sustained development of novel antibiotics is crucial. As over 60% of licensed antibiotics... Read More about Genome-guided bioprospecting for novel antibiotic lead compounds..

Identification of bacterial isolates recovered from the surface of cleanroom operators' garments following wear. (2022)
Journal Article
SMITH, L.M., LOWES, C., O'DRISCOLL, N.H. and LAMB, A.J. 2022. Identification of bacterial isolates recovered from the surface of cleanroom operators' garments following wear. European journal of parenteral and pharmaceutical sciences [online], 27(3), article number 27301. Available from: https://doi.org/10.37521/ejpps.27301

Contamination of sterile pharmaceutical products can have serious consequences, in worst case scenario resulting in patient death. Cleanroom operators are the primary source of microbial contamination, where the surface of their specialist sterile cl... Read More about Identification of bacterial isolates recovered from the surface of cleanroom operators' garments following wear..

A comparison of the bacterial contamination of the surface of cleanroom operators’ garments following donning with and without gloves. (2021)
Journal Article
SMITH, L.M., O'DRISCOLL, N.H. and LAMB, A.J. 2021. A comparison of the bacterial contamination of the surface of cleanroom operators’ garments following donning with and without gloves. European journal of parenteral and pharmaceutical sciences [online], 26(3). Available from: https://doi.org/10.37521/ejpps.26302

Specialist cleanroom garments are a potential vector for transmission of microorganisms within these facilities. In order to maintain the low bioburden of such clothing it has been perceived best practice for operators to dress wearing sterile cleanr... Read More about A comparison of the bacterial contamination of the surface of cleanroom operators’ garments following donning with and without gloves..

De novo genome assembly and analysis unveil biosynthetic and metabolic potentials of Pseudomonas fragi A13BB. [Dataset] (2021)
Data
AWOLOPE, O.K., O'DRISCOLL, N.H., DI SALVO, A. and LAMB, A.J. 2021. De novo genome assembly and analysis unveil biosynthetic and metabolic potentials of Pseudomonas fragi A13BB. [Dataset]. BMC genomic data [online], 22, article number 15. Available from: https://doi.org/10.1186/s12863-021-00969-0

Objectives; The role of rhizosphere microbiome in supporting plant growth under biotic stress is well documented. Rhizobacteria ward off phytopathogens through various mechanisms including antibiosis. We sought to recover novel antibiotic-producing b... Read More about De novo genome assembly and analysis unveil biosynthetic and metabolic potentials of Pseudomonas fragi A13BB. [Dataset].

The complete genome sequence of Hafnia alvei A23BA: a potential antibiotic-producing rhizobacterium. [Dataset] (2021)
Data
AWOLOPE, O.K., O'DRISCOLL, N.H., DI SALVO, A. and LAMB, A.J. 2021. The complete genome sequence of Hafnia alvei A23BA: a potential antibiotic-producing rhizobacterium. [Dataset]. BMC research notes [online], 14, article number 8. Available from: https://doi.org/10.1186/s13104-020-05418-2

Objectives: The urgent need for novel antibiotics cannot be overemphasized. Hafnia alvei A23BA was isolated from plant rhizosphere as part of an effort to recover novel antibiotic-producing bacterial strains from soil samples. The genome of the isola... Read More about The complete genome sequence of Hafnia alvei A23BA: a potential antibiotic-producing rhizobacterium. [Dataset].

Gender influences bacterial contamination of reusable cleanroom operators’ garments following wear. (2020)
Journal Article
SMITH, L.M., O'DRISCOLL, N.H. and LAMB, A.J. 2020. Gender influences bacterial contamination of reusable cleanroom operators’ garments following wear. European journal of parenteral and pharmaceutical sciences [online], 25(2), article 2. Available from: https://doi.org/10.37521/ejpps25202

Background: Operators are the primary source of cleanroom contamination, with the majority of their detritus identified as skin squames and their associated microorganisms. To reduce contamination, operatives are required to wear a specific arrangeme... Read More about Gender influences bacterial contamination of reusable cleanroom operators’ garments following wear..

Genome-guided screening of bacterial isolates to identify potential antibiotic producers. (2019)
Presentation / Conference Contribution
AWOLOPE, O.K., O'DRISCOLL, N.H. and LAMB, A. 2019. Genome-guided screening of bacterial isolates to identify potential antibiotic producers. Presented at the 2019 Microbiology Society annual conference, 8-11 April 2019, Belfast, UK.

The urgent need for new antibiotics cannot be overemphasized. Bacterial secondary metabolites remain a relatively untapped source of new therapies. The ability to produce these bioactive compounds is however not universal to all bacterial species. Tw... Read More about Genome-guided screening of bacterial isolates to identify potential antibiotic producers..

An investigation and examination of the levels and types of bacterial contamination on the surface of clean room operators' garments. (2018)
Thesis
SMITH, L.M. 2018. An investigation and examination of the levels and types of bacterial contamination on the surface of clean room operators' garments. Robert Gordon University, PhD thesis.

The contamination of sterile pharmaceutical products is a serious event which has in the worst case scenario led to patient death. Operators are the primary source of clean room contamination, with the majority of their detritus being identified as s... Read More about An investigation and examination of the levels and types of bacterial contamination on the surface of clean room operators' garments..

Colistin causes profound morphological alteration but minimal cytoplasmic membrane perforation in populations of Escherichia coli and Pseudomonas aeruginosa. (2018)
Journal Article
O'DRISCOLL, N.H., CUSHNIE, T.P.T., MATTHEWS, K.H. and LAMB, A.J. 2018. Colistin causes profound morphological alteration but minimal cytoplasmic membrane perforation in populations of escherichia coli and pseudomonas aeruginosa. Archives of microbiology [online], 200(5), pages 793-802. Available from: https://doi.org/10.1007/s00203-018-1485-3

Whilst colistin (polymyxin E) represents the last mainstream treatment option for multi-drug resistant Gram-negative pathogens, details of its mechanism of action remain to be fully resolved. In this study, the effects of sub-inhibitory, inhibitory-b... Read More about Colistin causes profound morphological alteration but minimal cytoplasmic membrane perforation in populations of Escherichia coli and Pseudomonas aeruginosa..

Morphological and ultrastructural changes in bacterial cells as an indicator of antibacterial mechanism of action. (2016)
Journal Article
CUSHNIE, T.P.T., O'DRISCOLL, N.H. and LAMB, A.J. 2016. Morphological and ultrastructural changes in bacterial cells as an indicator of antibacterial mechanism of action. Cellular and molecular life sciences [online], 73(23), pages 4471-4492. Available from: https://doi.org/10.1007/s00018-016-2302-2

Efforts to reduce the global burden of bacterial disease and contend with escalating bacterial resistance are spurring innovation in antibacterial drug and biocide development and related technologies such as photodynamic therapy and photochemical di... Read More about Morphological and ultrastructural changes in bacterial cells as an indicator of antibacterial mechanism of action..

Evaluation of the practice of veterinary pharmacy. (2015)
Journal Article
O'DRISCOLL, N.H., LABOVITIADI, O. and LAMB, A.J. 2015. Evaluation of the practice of veterinary pharmacy. Currents in pharmacy teaching and learning [online], 7(5), pages 606-613. Available from: https://doi.org/10.1016/j.cptl.2015.06.017

Background: In the United Kingdom (UK), pharmacists' roles have expanded considerably in recent decades to encompass clinical practice through more direct patient care. However, dispensing and compounding remain core activities for pharmacists. A lac... Read More about Evaluation of the practice of veterinary pharmacy..

Alkaloids: an overview of their antibacterial, antibiotic-enhancing and antivirulence activities. (2014)
Journal Article
CUSHNIE, T.P.T., CUSHNIE, B. and LAMB, A.J. 2014. Alkaloids: an overview of their antibacterial, anibiotic-enhancing and antivirulence activities. International journal of antimicrobial agents [online], 44(5), pages 377-386. Available from: https://doi.org/10.1016/j.ijantimicag.2014.06.001

With reports of pandrug-resistant bacteria causing untreatable infections, the need for new antibacterial therapies is more pressing than ever. Alkaloids are a large and structurally diverse group of compounds that have served as scaffolds for import... Read More about Alkaloids: an overview of their antibacterial, antibiotic-enhancing and antivirulence activities..

Veterinary pharmacy: coverage in the undergraduate pharmacy curriculum and perspectives of practising pharmacists. (2014)
Journal Article
O'DRISCOLL, N.H., JUWAH, C., LABOVITIADI, O. and LAMB, A.J. 2014. Veterinary pharmacy: coverage in the undergraduate pharmacy curriculum and perspectives of practising pharmacists. Pharmacy education [online], 14, pages 86-92. Available from: https://pharmacyeducation.fip.org/pharmacyeducation/article/view/196

The scope of tuition delivered in a School of Pharmacy in the UK on the topic of veterinary pharmacy appears to be centred on legislation and medicine supply under the veterinary cascade. This study sought the opinions of pharmacy undergraduate stude... Read More about Veterinary pharmacy: coverage in the undergraduate pharmacy curriculum and perspectives of practising pharmacists..

Veterinary pharmacy within the United Kingdom: review of current practice and education. (2014)
Journal Article
O'DRISCOLL, N.H., JUWAH, C., LABOVITIADI, O. and LAMB, A.J. 2014. Veterinary pharmacy within the United Kingdom: review of current practice and education. Pharmacy education [online], 14, pages 26-30. Available from: https://pharmacyeducation.fip.org/pharmacyeducation/article/view/188

Background: Pharmacists have acknowledged roles as medicines experts facilitating human healthcare. Such expertise is also applicable in pharmaceutical treatments for non-human animals. Aims: The aims were to review the perceptions and extent to whic... Read More about Veterinary pharmacy within the United Kingdom: review of current practice and education..

Examination of the antibacterial activities of some semi-synthetic chalcone-derivatives alone and in combination with polymyxin B. (2013)
Thesis
MEDU, E.O. 2013. Examination of the antibacterial activities of some semi-synthetic chalcone-derivatives alone and in combination with polymyxin B. Robert Gordon University, PhD thesis.

Bacterial resistance is an increasing challenge across the world, which means that there is an urgent need for the rational development of antibacterial compounds that have either novel or multiple mechanisms of action. This study demonstrated that t... Read More about Examination of the antibacterial activities of some semi-synthetic chalcone-derivatives alone and in combination with polymyxin B..

Antimicrobial wafers as a novel technology for infection control in chronic wounds. (2011)
Thesis
LABOVITIADI, O. 2011. Antimicrobial wafers as a novel technology for infection control in chronic wounds. Robert Gordon University, PhD thesis.

Bacterial contamination and persistent infection is a common cause of impaired wound healing. Generally, non-healing wounds display similar physiological features with regards to mixed bacterial flora, ischemia and production of exudate. The applicat... Read More about Antimicrobial wafers as a novel technology for infection control in chronic wounds..

Investigation into the antimicrobial activity of cationic antibacterials. (2011)
Thesis
O'DRISCOLL, N.H. 2011. Investigation into the antimicrobial activity of cationic antibacterials. Robert Gordon University, PhD thesis.

The topic addressed by the 2011 WHOs World Health Day was antibacterial resistance. This action served to highlight the serious problem bacterial resistance now presents to healthcare professionals globally. This investigation focussed on the action... Read More about Investigation into the antimicrobial activity of cationic antibacterials..

Aggregation of Staphylococcus aureus following treatment with the antibacterial flavonol galangin. (2007)
Journal Article
CUSHNIE, T.P.T., HAMILTON, V.E.S., CHAPMAN, D.G., TAYLOR, P.W. and LAMB, A.J. 2007. Aggregation of Staphylococcus aureus following treatment with the antibacterial flavonol galangin. Journal of applied microbiology [online], 103(5), pages 1562-1567. Available from: https://doi.org/10.1111/j.1365-2672.2007.03393.x

Aim: The flavonol galangin, an antimicrobial constituent of the traditional medicines propolis and Helichrysum aureonitens, is being assessed as part of an ongoing investigation into the antibacterial activity of flavonoids. The present study sought... Read More about Aggregation of Staphylococcus aureus following treatment with the antibacterial flavonol galangin..

The managed entry of new drugs into a National Health Service: a case study for Malta. (2003)
Thesis
BONANNO, P.V. 2003. The managed entry of new drugs into a National Health Service: a case study for Malta. Robert Gordon University, PhD thesis.

The research question was to determine if it is possible to develop a systematic approach to the managed entry of new drugs into a National Health Service( NHS), using Malta as a case study. In early 1999, Malta had major problems with the managed en... Read More about The managed entry of new drugs into a National Health Service: a case study for Malta..

Investigation of mesophilic Aeromonas: response to hydrogen peroxide and role in false-positive Colilert reaction. (1999)
Thesis
LANDRÉ, J.B.P. 1999. Investigation of mesophilic Aeromonas: response to hydrogen peroxide and role in false-positive Colilert reaction. Robert Gordon University, PhD thesis.

Mesophilic Aeromonas are opportunistic human pathogens which produce a wide range of virulence factors and have been isolated from both untreated and chlorinated drinking waters. The presence of these microorganisms in the distribution systems sugges... Read More about Investigation of mesophilic Aeromonas: response to hydrogen peroxide and role in false-positive Colilert reaction..