All Outputs (6)

Short-term oral administration of the Porcupine inhibitor, Wnt-c59, improves the structural and functional features of experimental HFpEF. (2025)
Journal Article
WALSH, S.K. [2025]. Short-term oral administration of the Porcupine inhibitor, Wnt-c59, improves the structural and functional features of experimental HFpEF. Pharmacology research and perspectives [online], (accepted).

Heart failure with preserved ejection fraction (HFpEF) accounts for approximately 50% of heart failure cases globally, and this incidence is increasing due to extended lifespans and accumulating comorbidities. Emerging evidence suggests that Wnt sign... Read More about Short-term oral administration of the Porcupine inhibitor, Wnt-c59, improves the structural and functional features of experimental HFpEF..

Evaluation of NACA and diNACA in human cystinosis fibroblast cell cultures as potential treatments for cystinosis. (2022)
Journal Article
HECTOR, E., CAIRNS, D. and WALL, G.W. 2022. Evaluation of NACA and diNACA in human cystinosis fibroblast cell cultures as potential treatments for cystinosis. Orphanet journal of rare diseases [online], 17, article 231. Available from: https://doi.org/10.1186/s13023-022-02367-w

Background: Cystinosis is a rare autosomal recessive lysosomal storage disease, associated with high morbidity and mortality. Mutations in the CTNS gene disable a membrane protein responsible for the transport of cystine out of the lysosome. Loss of... Read More about Evaluation of NACA and diNACA in human cystinosis fibroblast cell cultures as potential treatments for cystinosis..

Exploring the role of Wnt signalling in heart failure with preserved ejection fraction. (2022)
Thesis
PAUL, M.A. 2022. Exploring the role of Wnt signalling in heart failure with preserved ejection fraction. Robert Gordon University, PhD thesis. Hosted on OpenAIR [online]. Available from: https://doi.org/10.48526/rgu-wt-1987960

According to the European Society of Cardiology long-term out-patient registry, heart failure with preserved ejection fraction (HFpEF) accounts for approximately 16% of heart failure cases, with survival rates failing to improve due to the lack of ef... Read More about Exploring the role of Wnt signalling in heart failure with preserved ejection fraction..

Time above the MIC of piperacillin-tazobactam as a predictor of outcome in pseudomonas aeruginosa bacteraemia. (2020)
Journal Article
TANNOUS, E., LIPMAN, S., TONNA, A., HECTOR, E., HUSSEIN, Z., STEIN, M., and REISFELD, S. 2020. Time above the minimum inhibitory concentration of piperacillin/tazobactam as a predictor of outcome in Pseudomonas aeruginosa bacteraemia. Antimicrobial agents and chemotherapy [online], 64(8), article ID e02571-19. Available from: https://doi.org/10.1128/AAC.02571-19

All rights reserved. Pseudomonas aeruginosa bacteremia is an infection associated with a high mortality rate. Piperacillin-tazobactam is a β-lactam-β-lactamase inhibitor combination that is frequently used for the management of Pseudomonas aeruginosa... Read More about Time above the MIC of piperacillin-tazobactam as a predictor of outcome in pseudomonas aeruginosa bacteraemia..

GPR55 deletion in mice leads to age-related ventricular dysfunction and impaired adrenoceptor-mediated inotropic responses. (2014)
Journal Article
WALSH, S.K., HECTOR, E.E., ANDREASSON, A.-C., JONSSON-RYLANDER, A.-C. and WAINWRIGHT, C. L. 2014. GPR55 deletion in mice leads to age-related ventricular dysfunction and impaired adrenoceptor-mediated inotropic responses. PLoS ONE [online], 9(10), article number e108999. Available from: https://doi.org/10.1371/journal.pone.0108999

G protein coupled receptor 55 (GPR55) is expressed throughout the body and, although its exact physiological function is unknown, studies have suggested that it has a role in the cardiovascular system. In particular, GPR55 has been proposed as mediat... Read More about GPR55 deletion in mice leads to age-related ventricular dysfunction and impaired adrenoceptor-mediated inotropic responses..

Molecular mechanisms of nutrient mediated regulation of hypoxia inducible factor -1a(HIF-1a) in endothelial cells. (2007)
Thesis
HECTOR, E.E. 2007. Molecular mechanisms of nutrient mediated regulation of hypoxia inducible factor -1a(HIF-1a) in endothelial cells. Robert Gordon University, PhD thesis.

Poorly-controlled diabetes mellitus is associated with the development of chronic vascular complications, which cause morbidity and premature mortality. Many studies have highlighted that maintenance of normal blood glucose levels in all people with... Read More about Molecular mechanisms of nutrient mediated regulation of hypoxia inducible factor -1a(HIF-1a) in endothelial cells..