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Molecular aspects of the link between obesity, insulin resistance and breast cancer. (2010)
Thesis
WEICHHAUS, M.G. 2010. Molecular aspects of the link between obesity, insulin resistance and breast cancer. Robert Gordon University, PhD thesis.

Obesity is a multi-factorial metabolic disease, resulting in increased adipose tissue acquisition by the host. This disease increases the risk for developing co-morbidities, including Metabolic Syndrome and other disorders such as breast cancer. Obes... Read More about Molecular aspects of the link between obesity, insulin resistance and breast cancer..

Novel bisnaphthalimidopropyl polyamine derivatives: their mode of action in a breast cancer cell system. (2010)
Thesis
BARRON, G. 2010. Novel bisnaphthalimidopropyl polyamine derivatives: their mode of action in a breast cancer cell system. Robert Gordon University, PhD thesis.

The synthesis and characterisation of novel bisnaphthalimidopropyl polyamine (BNIPP) derivatives has gained pace over the last couple of years, as they have enhanced aqueous solubility without loss of biological activity in contrast to parent bisnaph... Read More about Novel bisnaphthalimidopropyl polyamine derivatives: their mode of action in a breast cancer cell system..

Insulin-induced gene expression changes in breast cancer cells and normal breast epithelial cells. (2009)
Presentation / Conference
WEICHHAUS, M., BROOM, J., WAHLE, K., HEYS, S. and BERMANO, G. 2009. Insulin-induced gene expression changes in breast cancer cells and normal breast epithelial cells. Presented at 17th European congress on obesity 2009 (ECO 2009), 6-9 May 2009, Amsterdam, Netherlands.

Obesity increases breast cancer incidence rates in postmenopausal women. Chronic high levels of insulin, present in the majority of obese and insulin resistant patients, may provide the growth promoting stimulus to explain this connection. In this wo... Read More about Insulin-induced gene expression changes in breast cancer cells and normal breast epithelial cells..

Molecular aspects linking insulin resistance to breast cancer by activation of cell signalling pathways. (2008)
Presentation / Conference
WEICHHAUS, M., BROOM, J., WAHLE, K. and BERMANO, G. 2008. Molecular aspects linking insulin resistance to breast cancer by activation of cell signalling pathways. Presented at 6th annual World congress on insulin resistance syndrome 2008 (WCIRS 2008), 25-27 September 2008, Los Angeles, U.S.A.

Recent findings suggest a connection between obesity and breast cancer. Obesity is linked with higher incidences of insulin resistance as part of the metabolic syndrome, resulting in chronically elevated insulin plasma levels. We examined the effect... Read More about Molecular aspects linking insulin resistance to breast cancer by activation of cell signalling pathways..

Molecular aspects of insulin resistance, cell signaling pathways and breast cancer in relation to obesity. (2008)
Presentation / Conference
WEICHHAUS, M., BROOM, J., WAHLE, K. and BERMANO, G. 2008. Molecular aspects of insulin resistance, cell signaling pathways and breast cancer in relation to obesity. Presented at 16th European congress on obesity 2008 (ECO 2008), 14-17 May 2008, Geneva, Switzerland.

A growing number of clinical studies validate a relation of insulin resistance and breast cancer in obese patients. We hypothesised that high plasma insulin levels cause aberrant insulin signalling in breast epithelial cells which may be responsible... Read More about Molecular aspects of insulin resistance, cell signaling pathways and breast cancer in relation to obesity..

Selenoprotein gene expression in an intestinal cell line during selenium depletion: a macroarray approach indicates effects on SelW and glutathione peroxidise 1. (2003)
Journal Article
PAGMANTIDIS, V., VILLETTE, S., BERMANO, G., BROOM, J., ARTHUR, J.R. and HESKETH, J.E. 2003. Selenoprotein gene expression in an intestinal cell line during selenium depletion: a macroarray approach indicates effects on SelW and glutathione peroxidise 1. Proceedings of the Nutrition Society [online], 62(1A), page 72A. Available from: https://doi.org/10.1017/S0029665103000776

The micronutrient selenium (Se) is incoprprated into a renage of selenoproteins involved in numerous biochemical processes within the body.