All Outputs (3)

Development, characterisation and neuroprotective effects of polymer-drug conjugate nano-polyplex: working towards a multi-target treatment for neurodegenerative diseases. (2025)
Journal Article
THOMPSON, C., BARRON, G.A., KONG THOO LIN, P. and MAHADIK, N. [2025]. Development, characterisation and neuroprotective effects of polymer-drug conjugate nano-polyplex: working towards a multi-target treatment for neurodegenerative diseases. Materials advances [online], Accepted Manuscripts. Available from: https://doi.org/10.1039/D5MA00174A

Neurodegenerative diseases (NDs) are complex, multifaceted conditions that require novel, multi-targeted therapeutic approaches. This study aimed to develop a multifunctional polymer-drug conjugate (PDC) by employing a novel strategy of utilizing PDC... Read More about Development, characterisation and neuroprotective effects of polymer-drug conjugate nano-polyplex: working towards a multi-target treatment for neurodegenerative diseases..

Synthesis and evaluation of polymer-drug conjugates as potential antioxidant and cholinesterase inhibitors for neurodegenerative diseases. (2024)
Journal Article
MAHADIK, N., BARRON, G., KONG THOO LIN, P. and THOMPSON, C. 2024. Synthesis and evaluation of polymer-drug conjugates as potential antioxidant and cholinesterase inhibitors for neurodegenerative diseases. Chemistry of materials [online], 36(21), pages 10514-10527. Available from: https://doi.org/10.1021/acs.chemmater.4c01767

Polymer-drug conjugates (PDCs) may offer improved water-solubility and in vitro activity of potential antioxidant and cholinesterase (ChE) inhibitor drugs compared to the drugs alone. Conjugation of these potential drugs to water-soluble polymers cou... Read More about Synthesis and evaluation of polymer-drug conjugates as potential antioxidant and cholinesterase inhibitors for neurodegenerative diseases..

Polymer-drug conjugates as nano-sized multi-targeting systems for the treatment of Alzheimer's disease. (2024)
Journal Article
MAHADIK, N., BARRON, G.A., KONG THOO LIN, P. and THOMPSON, C.J. 2024. Polymer-drug conjugates as nano-sized multi-targeting systems for the treatment of Alzheimer's disease. RSC pharmaceutics [online], 1(2), pages 161-181. Available from: https://doi.org/10.1039/D3PM00075C

Alzheimer's disease (AD) is a progressive, neurodegenerative condition. There are clear markers for the presence and progression of the disease, including β-amyloid (Aβ) plaques and Tau tangles, with many potential causes debated in the scientific co... Read More about Polymer-drug conjugates as nano-sized multi-targeting systems for the treatment of Alzheimer's disease..