All Outputs (6)

Synthesis and evaluation of novel multi-target compounds for the treatment of Alzheimer's disease. (2022)
Thesis
BLAIKIE, L.M. 2022 Synthesis and evaluation of novel multi-target compounds for the treatment of alzheimer's disease. Robert Gordon University, PhD thesis. Hosted on OpenAIR [online]. Available from: https://doi.org/10.48526/rgu-wt-3027109

Alzheimer's disease (AD) is the most common neurodegenerative disease, and a major cause of death worldwide. The prevalence of this debilitating disorder is rising exponentially, and there is an urgent unmet need for a cure. AD is a complex, multifac... Read More about Synthesis and evaluation of novel multi-target compounds for the treatment of Alzheimer's disease..

Synthesis of novel vanillin derivatives: study of their antioxidant and potential neuroprotective properties. (2019)
Thesis
SCIPIONI, M. 2019. Synthesis of novel vanillin derivatives: study of their antioxidant and potential neuroprotective properties. Robert Gordon University [online], PhD thesis. Available from: https://openair.rgu.ac.uk

Vanillin (4-hydroxy-3-methoxybenzaldehyde) is a naturally-occurring phenolic compound, forming the main component of the bean and pod of vanilla orchids. It is widely used as a flavouring agent in food and drinks, and as a preservative in the cosmeti... Read More about Synthesis of novel vanillin derivatives: study of their antioxidant and potential neuroprotective properties..

The design, synthesis and evaluation of selective, non invasive imaging agents for atherosclerotic plaque. (2017)
Thesis
JESUDOSS, J.R. 2017. The design, synthesis and evaluation of selective, non invasive imaging agents for atherosclerotic plaque. Robert Gordon University, MPhil thesis.

The aim of this research study was the synthesis of an imaging agent, which could be used to non-invasively image atherosclerotic plaques via MRI. In order to achieve this, a library of peptide substrates designed to be substrate specific for either... Read More about The design, synthesis and evaluation of selective, non invasive imaging agents for atherosclerotic plaque..

The design and synthesis of novel pro-drugs for the treatment of nephropathic cystinosis. (2015)
Thesis
BAHMED, A. 2015. The design and synthesis of novel pro-drugs for the treatment of nephropathic cystinosis. Robert Gordon University, PhD thesis.

Cystinosis is a metabolic disorder characterised by the abnormal accumulation of the amino acid cystine in cells leading to a slow destruction of all major organs. If patients diagnosed with cystinosis are untreated, death due to kidney failure ensue... Read More about The design and synthesis of novel pro-drugs for the treatment of nephropathic cystinosis..

Development of novel nutrapharmaceuticals combining the anti-oxidant and anti-inflammatory properties of n-3 fatty acids with a nitric oxide donor: a potential new preventative strategy for heart disease. (2011)
Thesis
ROWELL, O. 2011. Development of novel nutrapharmaceuticals combining the anti-oxidant and anti-inflammatory properties of n-3 fatty acids with a nitric oxide donor: a potential new preventative strategy for heart disease. Robert Gordon University, MRes thesis.

Atherosclerosis is a cardiovascular disease which forms plaques which narrow the arteries, restricting blood flow and thus increasing blood pressure. As this can lead to more serious conditions, such as myocardial infarction, it is important that ath... Read More about Development of novel nutrapharmaceuticals combining the anti-oxidant and anti-inflammatory properties of n-3 fatty acids with a nitric oxide donor: a potential new preventative strategy for heart disease..

Formulation studies on cysteamine for the treatment of nephropathic cystinosis. (2011)
Thesis
BUCHAN, B.E. 2011. Formulation studies on cysteamine for the treatment of nephropathic cystinosis. Robert Gordon University, PhD thesis.

Nephropathic cystinosis is a rare autosomal recessive disease characterised by raised lysosomal levels of cystine in the cells of almost all organs. It is treated by regular oral and topical administration of the aminothiol, cysteamine (Cystagon TM),... Read More about Formulation studies on cysteamine for the treatment of nephropathic cystinosis..