All Outputs (2)

Metabolic alterations in a rat model of takotsubo syndrome. (2021)
Journal Article
GODSMAN, N., KOHLHASS, M., NICKEL, A., CHEYNE, L., MINGARELLI, M., SCHWEIGHER, L., HEPBURN, C., MUNTS, C., WELCH, A., DELIBEGOVIC, M., BILSEN, M. VAN., MAACK, C. and DAWSON, D.K. 2022. Metabolic alterations in a rat model of takotsubo syndrome. Cardiovascular research [online], 118(8), pages 1932-1946. Available from: https://doi.org/10.1093/cvr/cvab081

Cardiac energetic impairment is a major finding in takotsubo patients. We investigate specific metabolic adaptations to direct future therapies. An isoprenaline-injection female rat model (vs. sham) was studied at Day 3; recovery assessed at Day 7. S... Read More about Metabolic alterations in a rat model of takotsubo syndrome..

Acute dietary zinc deficiency in rats exacerbates myocardial ischaemia-reperfusion injury through depletion of glutathione. (2019)
Journal Article
SKENE, K., WALSH, S.K., OKAFOR, O., GODSMAN, N., BARROWS, C., MEIER, P., GORDON, M.J., BEATTIE, J.H. and WAINWRIGHT, C.L. 2019. Acute dietary zinc deficiency in rats exacerbates myocardial ischaemia-reperfusion injury through depletion of glutathione. British journal of nutrition [online], 121(9), pages 961-973. Available from: https://doi.org/10.1017/S0007114519000230

Zinc (Zn) plays an important role in maintaining the anti-oxidant status within the heart, and helps to counter the acute redox stress that occurs during myocardial ischaemia and reperfusion. Individuals with low zinc (Zn) levels are at greater risk... Read More about Acute dietary zinc deficiency in rats exacerbates myocardial ischaemia-reperfusion injury through depletion of glutathione..