Outputs (4)

A novel in vitro model of the small intestinal epithelium in co-culture with "gut-like" dendritic cells. (2023)
Journal Article
JOHNSTON, L.J., BARNINGHAM, L., CAMPBELL, E.L., CEROVIC, V., DUCKWORTH, C.A., LUU, L., WASTLING, J., DERRICOTT, H. and COOMBES, J.L. 2023. A novel in vitro model of the small intestinal epithelium in co-culture with "gut-like" dendritic cells. Discovery immunology [online], 2(1), article number kyad018. Available from: https://doi.org/10.1093/discim/kyad018

Cross-talk between dendritic cells (DCs) and the intestinal epithelium is important in the decision to mount a protective immune response to a pathogen or to regulate potentially damaging responses to food antigens and the microbiota. Failures in thi... Read More about A novel in vitro model of the small intestinal epithelium in co-culture with "gut-like" dendritic cells..

Cleaved CD95L perturbs in vitro macrophages responses to Toxoplasma gondii. (2022)
Journal Article
TIFFNEY, E.A., COOMBES, J.L., LEGEMBRE, P. and FLYNN, R.J. 2022. Cleaved CD95L perturbs in vitro macrophages responses to Toxoplasma gondii. Microbes and infection [online], 24(5), article number 104952. Available from: https://doi.org/10.1016/j.micinf.2022.104952

Toxoplasma gondii infects approximately 1–2 billion people, and manipulation of the macrophage response is critical to host and parasite survival. A cleaved (cl)-CD95L form can promote cellular migration and we have previously shown that cl-CD95L agg... Read More about Cleaved CD95L perturbs in vitro macrophages responses to Toxoplasma gondii..

Bioengineering commensal bacteria-derived outer membrane vesicles for delivery of biologics to the gastrointestinal and respiratory tract. (2019)
Journal Article
CARVALHO, A.L., FONSECA, S., MIQUEL-CLOPÉS, A., CROSS, K., KOK, K.-S., WEGMANN, U., GIL-CARDOSO, K., BENTLEY, E.G., AL KATY, S.H.M., COOMBES, J.L., KIPAR, A., STENTZ, R., STEWART, J.P. and CARDING, S.R. 2019. Bioengineering commensal bacteria-derived outer membrane vesicles for delivery of biologics to the gastrointestinal and respiratory tract. Journal of extracellular vesicles [online], 8(1), article number 1632100. Available from: https://doi.org/10.1080/20013078.2019.1632100

Gram-negative bacteria naturally produce and secrete nanosized outer membrane vesicles (OMVs). In the human gastrointestinal tract, OMVs produced by commensal Gram-negative bacteria can mediate interactions amongst host cells (including between epith... Read More about Bioengineering commensal bacteria-derived outer membrane vesicles for delivery of biologics to the gastrointestinal and respiratory tract..

Parasitized natural killer cells do not facilitate the spread of toxoplasma gondii to the brain. (2018)
Journal Article
PETIT-JENTREAU, L., GLOVER, C. and COOMBES, J.L. 2018. Parasitized natural killer cells do not facilitate the spread of toxoplasma gondiito the brain. Parasite immunology [online], 40(4), article e12522. Available from: https://doi.org/10.1111/pim.12522

Toxoplasmagondii is a protozoan parasite capable of invading immune cells and co-opting their migratory pathways to disseminate through the host. Natural Killer (NK) cells can be directly invaded by the parasite and this invasion alters NK cell migra... Read More about Parasitized natural killer cells do not facilitate the spread of toxoplasma gondii to the brain..