Outputs (56)

DNA profiling of single sperm cells and single skin flakes in forensics using micromanipulation and whole genome amplification. (2020)
Thesis
THEUNISSEN, G.M.G. 2020. DNA profiling of single sperm cells and single skin flakes in forensics using micromanipulation and whole genome amplification. Robert Gordon University [online], PhD thesis. Available from: https://openair.rgu.ac.uk

In forensic DNA profiling, the occurrence of complex mixed profiles is currently a common issue. Cases involving intimate swabs or skin flake tape liftings are prone to mixed profiles, because of more than one donor contributing to a DNA sample. By D... Read More about DNA profiling of single sperm cells and single skin flakes in forensics using micromanipulation and whole genome amplification..

GST-4-dependent suppression of neurodegeneration in C. elegans models of Parkinson’s and Machado-Joseph Disease by rapeseed pomace extract supplementation. (2019)
Journal Article
POHL, F., TEIXEIRA-CASTRO, A., COSTA, M.D., LINDSAY, V., FIÚZA-FERNANDES, J., GOUA, M., BERMANO, G., RUSSELL, W., MACIEL, P. and KONG THOO LIN, P. 2019. GST-4-dependent suppression of neurodegeneration in C. elegans models of Parkinson’s and Machado-Joseph Disease by rapeseed pomace extract supplementation. Frontiers in neuroscience [online], 13, article ID 1091. Available from: https://doi.org/10.3389/fnins.2019.01091

Genetic mutations and aging-associated oxidative damage underlie the onset and progression of neurodegenerative diseases, like Parkinson’s disease (PD) and Machado-Joseph disease (MJD). Natural products derived from plants have been regarded as impor... Read More about GST-4-dependent suppression of neurodegeneration in C. elegans models of Parkinson’s and Machado-Joseph Disease by rapeseed pomace extract supplementation..

Current and emerging therapeutic targets of alzheimer's disease for the design of multi-target directed ligands. (2019)
Journal Article
BLAIKIE, L., KAY, G. and KONG THOO LIN, P. 2019. Current and emerging therapeutic targets of alzheimer's disease for the design of multi-target directed ligands. MedChemComm [online], 10(12), pages 2052-2072. Available from: https://doi.org/10.1039/c9md00337a

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease, and a major cause of death worldwide. The number of people suffering from this debilitating disorder is rising at an unprecedented rate, with a subsequent surge in healthcare c... Read More about Current and emerging therapeutic targets of alzheimer's disease for the design of multi-target directed ligands..

Synthesis of novel vanillin derivatives: study of their antioxidant and potential neuroprotective properties. (2019)
Thesis
SCIPIONI, M. 2019. Synthesis of novel vanillin derivatives: study of their antioxidant and potential neuroprotective properties. Robert Gordon University [online], PhD thesis. Available from: https://openair.rgu.ac.uk

Vanillin (4-hydroxy-3-methoxybenzaldehyde) is a naturally-occurring phenolic compound, forming the main component of the bean and pod of vanilla orchids. It is widely used as a flavouring agent in food and drinks, and as a preservative in the cosmeti... Read More about Synthesis of novel vanillin derivatives: study of their antioxidant and potential neuroprotective properties..

Synthesis of novel vanillin derivatives: novel multi-targeted scaffold ligands against Alzheimer's disease. (2019)
Journal Article
SCIPIONI, M., KAY, G., MEGSON, I.L. and KONG THOO LIN, P. 2019. Synthesis of novel vanillin derivatives: novel multi-targeted scaffold ligands against Alzheimer’s disease. MedChemComm [online], 10(5), pages 764-777. Available from: https://doi.org/10.1039/c9md00048h

Alzheimer’s Disease (AD) is the most common cause of dementia worldwide, normally affecting people aged over 65. Due to the multifactorial nature of this disease, a “multi-target-directed ligands” (MTDLs) approach for the treatment of this illness ha... Read More about Synthesis of novel vanillin derivatives: novel multi-targeted scaffold ligands against Alzheimer's disease..

The potential application of rapeseed pomace extracts in the prevention and treatment of neurodegenerative diseases. (2019)
Thesis
POHL, F. 2019. The potential application of rapeseed pomace extracts in the prevention and treatment of neurodegenerative diseases. Robert Gordon University [online], PhD thesis. Available from: https://openair.rgu.ac.uk

Rapeseed pomace (RSP) is the waste/by-product obtained after edible oil production from Brassica napus and is currently used as animal feed. In an attempt to revalorize this by-product as a potential nutraceutical for the treatment or prevention of n... Read More about The potential application of rapeseed pomace extracts in the prevention and treatment of neurodegenerative diseases..

The potential use of plant natural products and plant extracts with antioxidant properties for the prevention/treatment of neurodegenerative diseases: in vitro, in vivo and clinical trials. (2018)
Journal Article
POHL, F. and KONG THOO LIN, P. 2018. The potential use of plant natural products and plant extracts with antioxidant properties for the prevention/treatment of neurodegenerative diseases: in vitro, in vivo and clinical trials. Molecules [online], 23(12), article ID 3283. Available from: https://doi.org/10.3390/molecules23123283

Neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease and Huntington's disease, present a major health issue and financial burden for health care systems around the world. The impact of these diseases will further increase o... Read More about The potential use of plant natural products and plant extracts with antioxidant properties for the prevention/treatment of neurodegenerative diseases: in vitro, in vivo and clinical trials..

Determination of sinapine in rapeseed pomace extract: its antioxidant and acetylcholinesterase inhibition properties. (2018)
Journal Article
YATES, K., POHL, F., BUSCH, M., MOZER, A., WATTERS, L., SHIRYAEV, A. and KONG THOO LIN, P. 2019. Determination of sinapine in rapeseed pomace extract: its antioxidant and acetylcholinesterase inhibition properties. Food chemistry [online], 276, pages 768-775. Available from: https://doi.org/10.1016/j.foodchem.2018.10.045

Sinapine is the main secondary metabolite present in rapeseed pomace (RSP) with its concentration being dependent on rapeseed processing, growing conditions, extraction parameters and the country of origin. Here we report, the concentration of sinapi... Read More about Determination of sinapine in rapeseed pomace extract: its antioxidant and acetylcholinesterase inhibition properties..

A novel PAA derivative with enhanced drug efficacy in pancreatic cancer cell lines. (2018)
Journal Article
ALSURAIFI, A., KONG THOO LIN, P., CURTIS, A., LAMPROU, D.A. and HOSKINS, C. 2018. A novel PAA derivative with enhanced drug efficacy in pancreatic cancer cell lines. Pharmaceuticals [online], 11(4), article ID 91. Available from: https://doi.org/10.3390/ph11040091

Nanoparticles have been shown to be effective drug carriers in cancer therapy. Pancreatic cancer forms dense tumours which are often resistant to drug molecules. In order to overcome such multidrug resistance, new drug entities, novel delivery system... Read More about A novel PAA derivative with enhanced drug efficacy in pancreatic cancer cell lines..

Caspase-independence and characterization of bisnaphthalimidopropyl spermidine induced cytotoxicity in HL60 cells. (2018)
Journal Article
BESTWICK, C., MILNE, L., DANCE, A.-M., COCHENNEC, G., CRUICKSHANK, G., ALLAIN, E., CONSTABLE, L., DUTHIE, S.J. and KONG THOO LIN, P. 2018. Caspase-independence and characterization of bisnaphthalimidopropyl spermidine induced cytotoxicity in HL60 cells. Toxicology in vitro [online], 52, pages 342-350. Available from: https://doi.org/10.1016/j.tiv.2018.06.023

Bisnaphthalimides are DNA intercalators of potential use as chemotherapeutics but for which the range of mechanism of action is only gradually being elucidated. Using human promyelocytic HL-60 cells, we extend characterization of the cytotoxicity of... Read More about Caspase-independence and characterization of bisnaphthalimidopropyl spermidine induced cytotoxicity in HL60 cells..