Outputs (16)

Oral human papillomavirus infection in England and associated risk factors: a case control study. (2018)
Journal Article
HEARNDEN, V., MURDOCH, C., D'APICE, K., DUTHIE, S., HAYWARD, N.J. and POWERS, H.J. 2018. Oral human papillomavirus infection in England and associated risk factors: a case control study. BMJ open [online], 8(8), article number 022497. Available from: https://doi.org/10.1136/bmjopen-2018-022497

Objectives - This study was conducted to determine the prevalence of and associated risk factors for infection with oral high-risk human papillomavirus (HR-HPV) in adult participants within England, and to explore any association with oral mucosal bu... Read More about Oral human papillomavirus infection in England and associated risk factors: a case control study..

Caspase-independence and characterization of bisnaphthalimidopropyl spermidine induced cytotoxicity in HL60 cells. (2018)
Journal Article
BESTWICK, C., MILNE, L., DANCE, A.-M., COCHENNEC, G., CRUICKSHANK, G., ALLAIN, E., CONSTABLE, L., DUTHIE, S.J. and KONG THOO LIN, P. 2018. Caspase-independence and characterization of bisnaphthalimidopropyl spermidine induced cytotoxicity in HL60 cells. Toxicology in vitro [online], 52, pages 342-350. Available from: https://doi.org/10.1016/j.tiv.2018.06.023

Bisnaphthalimides are DNA intercalators of potential use as chemotherapeutics but for which the range of mechanism of action is only gradually being elucidated. Using human promyelocytic HL-60 cells, we extend characterization of the cytotoxicity of... Read More about Caspase-independence and characterization of bisnaphthalimidopropyl spermidine induced cytotoxicity in HL60 cells..

Roadmap for investigating epigenome deregulation and environmental origins of cancer. (2017)
Journal Article
HERCEG, Z., GHANTOUS, A., WILD, C.P., SKLIAS, A., CASATI, L., DUTHIE, S.J., FRY, R., ISSA, J.-P., KELLERMAYER, R., KOTURBASH, I., KONDO, Y., LEPEULE, J., LIMA, S.C.S., MARSIT, C.J., RAKYAN, V., SAFFERY, R., TAYLOR, J.A., TESCHENDORFF, A.E., USHIJIMA, T., VINEIS, P., WALKER, C.L., WATERLAND, R.A., WIEMELS, J., AMBATIPUDI, S., ESPOSTI, D.D. and HERNANDEZ-VARGAS, H. 2017. Roadmap for investigating epigenome deregulation and environmental origins of cancer. International journal of cancer [online], 142(5), pages 874-882. Available from: https://doi.org/10.1002/ijc.31014

The interaction between the (epi)genetic makeup of an individual and his/her environmental exposure record (exposome) is accepted as a determinant factor for a significant proportion of human malignancies. Recent evidence has highlighted the key role... Read More about Roadmap for investigating epigenome deregulation and environmental origins of cancer..

Effect of increasing fruit and vegetable intake by dietary intervention on nutritional biomarkers and attitudes to dietary change: a randomised trial. (2017)
Journal Article
DUTHIE, S.J., DUTHIE, G.G., RUSSELL, W.R., KYLE, J.A.M., MACDIARMID, J.I., RUNGAPAMESTRY, V., STEPHEN, S., MEGIAS-BAEZA, C., KANIEWSKA, J.J., SHAW, L., MILNE, L., BREMNER, D., ROSS, K., MORRICE, P., PIRIE, L.P., HORGAN, G. and BESTWICK, C.S. 2018. Effect of increasing fruit and vegetable intake by dietary intervention on nutritional biomarkers and attitudes to dietary change: a randomised trial. European journal of nutrition [online], 57(5), pages 1855-1872. Available from: https://doi.org/10.1007/s00394-017-1469-0

Low fruit and vegetable consumption is linked with an increased risk of death from vascular disease and cancer. The benefit of eating fruits and vegetables is attributed in part to antioxidants, vitamins and phytochemicals. Whether increasing intake... Read More about Effect of increasing fruit and vegetable intake by dietary intervention on nutritional biomarkers and attitudes to dietary change: a randomised trial..

Nutritional B vitamin deficiency alters the expression of key proteins associated with vascular smooth muscle cell proliferation and migration in the aorta of atherosclerotic apolipoprotein E null mice. (2014)
Journal Article
DUTHIE, S.J., BEATTIE, J.H., GORDON, M.-J., PIRIE, L.P., NICOL, F., REID, M.D., DUNCAN, G.J., CANTLAY, L., HORGAN, G. and MCNEIL, C.J. 2015. Nutritional B vitamin deficiency alters the expression of key proteins associated with vascular smooth muscle cell proliferation and migration in the aorta of atherosclerotic apolipoprotein E null mice. Genes and nutrition [online], 10(1), article 446. Available from: https://doi.org/10.1007/s12263-014-0446-y

Low B vitamin status is linked with human vascular disease. We employed a proteomic and biochemical approach to determine whether nutritional folate deficiency and/or hyperhomocysteinemia altered metabolic processes linked with atherosclerosis in Apo... Read More about Nutritional B vitamin deficiency alters the expression of key proteins associated with vascular smooth muscle cell proliferation and migration in the aorta of atherosclerotic apolipoprotein E null mice..

Transcriptome analysis of peripheral blood mononuclear cells in human subjects following a 36 h fast provides evidence of effects on genes regulating inflammation, apoptosis and energy metabolism. (2014)
Journal Article
ELLIOTT, R.M., DE ROOS, B., DUTHIE, S.J., BOUWMAN, F.G., RUBIO-ALIAGA, I., CROSLEY, L.K., MAYER, C., POLLEY, A.C., HEIM, C., COORT, S.L., EVELO, C.T., MULHOLLAND, F., DANIEL, H., MARIMAN, E.C. and JOHNSON, I.T. 2014. Transcriptome analysis of peripheral blood mononuclear cells in human subjects following a 36 h fast provides evidence of effects on genes regulating inflammation, apoptosis and energy metabolism. Genes and nutrition [online], 9(6), article 432. Available from: https://doi.org/10.1007/s12263-014-0432-4

There is growing interest in the potential health benefits of diets that involve regular periods of fasting. While animal studies have provided compelling evidence that feeding patterns such as alternate-day fasting can increase longevity and reduce... Read More about Transcriptome analysis of peripheral blood mononuclear cells in human subjects following a 36 h fast provides evidence of effects on genes regulating inflammation, apoptosis and energy metabolism..