Zdenko Herceg
Roadmap for investigating epigenome deregulation and environmental origins of cancer.
Herceg, Zdenko; Ghantous, Akram; Wild, Christopher P.; Sklias, Athena; Casati, Lavinia; Duthie, Susan J.; Fry, Rebecca; Issa, Jean‐Pierre; Kellermayer, Richard; Koturbash, Igor; Kondo, Yukata; Lepeule, Johanna; Lima, Sheila C.S.; Marsit, Carmen J.; Rakyan, Vardhman; Saffery, Richard; Taylor, Jack A.; Teschendorff, Andrew E.; Ushijima, Toshikazu; Vineis, Paolo; Walker, Cheryl Lyn; Waterland, Robert A.; Wiemels, Joe; Ambatipudi, Srikant; Esposti, Davide Degli; Hernandez‐Vargas, Hector
Authors
Akram Ghantous
Christopher P. Wild
Athena Sklias
Lavinia Casati
Susan J. Duthie
Rebecca Fry
Jean‐Pierre Issa
Richard Kellermayer
Igor Koturbash
Yukata Kondo
Johanna Lepeule
Sheila C.S. Lima
Carmen J. Marsit
Vardhman Rakyan
Richard Saffery
Jack A. Taylor
Andrew E. Teschendorff
Toshikazu Ushijima
Paolo Vineis
Cheryl Lyn Walker
Robert A. Waterland
Joe Wiemels
Srikant Ambatipudi
Davide Degli Esposti
Hector Hernandez‐Vargas
Abstract
The interaction between the (epi)genetic makeup of an individual and his/her environmental exposure record (exposome) is accepted as a determinant factor for a significant proportion of human malignancies. Recent evidence has highlighted the key role of epigenetic mechanisms in mediating gene-environment interactions and translating exposures into tumorigenesis. There is also growing evidence that epigenetic changes may be risk factor-specific ('fingerprints') that should prove instrumental in the discovery of new biomarkers in cancer. Here, we review the state of the science of epigenetics associated with environmental stimuli and cancer risk, highlighting key developments in the field. Critical knowledge gaps and research needs are discussed as well as advances in epigenomics that may help an understanding of the functional relevance of epigenetic alterations. Key elements required for causality inferences linking epigenetic changes to exposure and cancer are discussed as well as how these alterations can be incorporated in carcinogen evaluation and in understanding mechanisms underlying epigenome deregulation by the environment.
Journal Article Type | Article |
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Publication Date | Mar 1, 2018 |
Journal | International journal of cancer |
Print ISSN | 0020-7136 |
Electronic ISSN | 1097-0215 |
Publisher | Wiley Open Access |
Peer Reviewed | Peer Reviewed |
Volume | 142 |
Issue | 5 |
Pages | 874-882 |
Institution Citation | HERCEG, Z., GHANTOUS, A., WILD, C.P., SKLIAS, A., CASATI, L., DUTHIE, S.J., FRY, R., ISSA, J.-P., KELLERMAYER, R., KOTURBASH, I., KONDO, Y., LEPEULE, J., LIMA, S.C.S., MARSIT, C.J., RAKYAN, V., SAFFERY, R., TAYLOR, J.A., TESCHENDORFF, A.E., USHIJIMA, T., VINEIS, P., WALKER, C.L., WATERLAND, R.A., WIEMELS, J., AMBATIPUDI, S., ESPOSTI, D.D. and HERNANDEZ-VARGAS, H. 2017. Roadmap for investigating epigenome deregulation and environmental origins of cancer. International journal of cancer [online], 142(5), pages 874-882. Available from: https://doi.org/10.1002/ijc.31014 |
DOI | https://doi.org/10.1002/ijc.31014 |
Keywords | Epigenetics; Environment; Cancer; Molecular mechanisms; Research gaps; Perspectives; Biomarkers |
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