Roadmap for investigating epigenome deregulation and environmental origins of cancer.

Herceg, Zdenko; Ghantous, Akram; Wild, Christopher P.; Sklias, Athena; Casati, Lavinia; Duthie, Susan J.; Fry, Rebecca; Issa, Jean?Pierre; Kellermayer, Richard; Koturbash, Igor; Kondo, Yukata; Lepeule, Johanna; Lima, Sheila C.S.; Marsit, Carmen J.; Rakyan, Vardhman; Saffery, Richard; Taylor, Jack A.; Teschendorff, Andrew E.; Ushijima, Toshikazu; Vineis, Paolo; Walker, Cheryl Lyn; Waterland, Robert A.; Wiemels, Joe; Ambatipudi, Srikant; Esposti, Davide Degli; Hernandez?Vargas, Hector

doi:10.1002/ijc.31014

Roadmap for investigating epigenome deregulation and environmental origins of cancer.

Herceg, Zdenko; Ghantous, Akram; Wild, Christopher P.; Sklias, Athena; Casati, Lavinia; Duthie, Susan J.; Fry, Rebecca; Issa, Jean?Pierre; Kellermayer, Richard; Koturbash, Igor; Kondo, Yukata; Lepeule, Johanna; Lima, Sheila C.S.; Marsit, Carmen J.; Rakyan, Vardhman; Saffery, Richard; Taylor, Jack A.; Teschendorff, Andrew E.; Ushijima, Toshikazu; Vineis, Paolo; Walker, Cheryl Lyn; Waterland, Robert A.; Wiemels, Joe; Ambatipudi, Srikant; Esposti, Davide Degli; Hernandez?Vargas, Hector

Authors

Zdenko Herceg

Akram Ghantous

Christopher P. Wild

Athena Sklias

Lavinia Casati

Professor Susan Duthie s.j.duthie@rgu.ac.uk
Associate Head of School

Rebecca Fry

Jean?Pierre Issa

Richard Kellermayer

Igor Koturbash

Yukata Kondo

Johanna Lepeule

Sheila C.S. Lima

Carmen J. Marsit

Vardhman Rakyan

Richard Saffery

Jack A. Taylor

Andrew E. Teschendorff

Toshikazu Ushijima

Paolo Vineis

Cheryl Lyn Walker

Robert A. Waterland

Joe Wiemels

Srikant Ambatipudi

Davide Degli Esposti

Hector Hernandez?Vargas

Abstract

The interaction between the (epi)genetic makeup of an individual and his/her environmental exposure record (exposome) is accepted as a determinant factor for a significant proportion of human malignancies. Recent evidence has highlighted the key role of epigenetic mechanisms in mediating gene-environment interactions and translating exposures into tumorigenesis. There is also growing evidence that epigenetic changes may be risk factor-specific ('fingerprints') that should prove instrumental in the discovery of new biomarkers in cancer. Here, we review the state of the science of epigenetics associated with environmental stimuli and cancer risk, highlighting key developments in the field. Critical knowledge gaps and research needs are discussed as well as advances in epigenomics that may help an understanding of the functional relevance of epigenetic alterations. Key elements required for causality inferences linking epigenetic changes to exposure and cancer are discussed as well as how these alterations can be incorporated in carcinogen evaluation and in understanding mechanisms underlying epigenome deregulation by the environment.

Citation

HERCEG, Z., GHANTOUS, A., WILD, C.P., SKLIAS, A., CASATI, L., DUTHIE, S.J., FRY, R., ISSA, J.-P., KELLERMAYER, R., KOTURBASH, I., KONDO, Y., LEPEULE, J., LIMA, S.C.S., MARSIT, C.J., RAKYAN, V., SAFFERY, R., TAYLOR, J.A., TESCHENDORFF, A.E., USHIJIMA, T., VINEIS, P., WALKER, C.L., WATERLAND, R.A., WIEMELS, J., AMBATIPUDI, S., ESPOSTI, D.D. and HERNANDEZ-VARGAS, H. 2017. Roadmap for investigating epigenome deregulation and environmental origins of cancer. International journal of cancer [online], 142(5), pages 874-882. Available from: https://doi.org/10.1002/ijc.31014

Journal Article Type	Article
Acceptance Date	Aug 3, 2017
Online Publication Date	Aug 24, 2017
Publication Date	Mar 1, 2018
Deposit Date	Aug 28, 2017
Publicly Available Date	Aug 28, 2017
Journal	International journal of cancer
Print ISSN	0020-7136
Electronic ISSN	1097-0215
Publisher	Wiley Open Access
Peer Reviewed	Peer Reviewed
Volume	142
Issue	5
Pages	874-882
DOI	https://doi.org/10.1002/ijc.31014
Keywords	Epigenetics; Environment; Cancer; Molecular mechanisms; Research gaps; Perspectives; Biomarkers
Public URL	http://hdl.handle.net/10059/2475