Association between physical activity and immunogenicity of an inactivated virus vaccine against SARS-CoV-2 in patients with autoimmune rheumatic diseases. [Dataset]

Abstract

To investigate whether physical activity is associated with enhanced immunogenicity of a SARS-CoV-2 inactivated vaccine (Coronavac) in patients with autoimmune rheumatic diseases (ARD) (n = 898) and in non-ARD (n = 197) individuals without pre-existing immunogenicity to SARS-CoV-2. After SARS-CoV-2 vaccination, autoimmune rheumatic diseases (ARD) active patients had more antibodies than inactives. It was found that greatest vaccine responses were associated with physical activity of less than 350 min/week.

Citation

GUALANO, B., LEMES, I.R., SILVA, R.P. et al. 2022. Association between physical activity and immunogenicity of an inactivated virus vaccine against SARS-CoV-2 in patients with autoimmune rheumatic diseases. [Dataset]. Brain, behavior and immunity [online], 101, pages 49-56. Available from: https://www.sciencedirect.com/science/article/pii/S0889159121006474?via%3Dihub#s0095

• Acceptance Date: Dec 18, 2021
• Online Publication Date: Dec 23, 2021
• Publication Date: Mar 31, 2022
• Deposit Date: Feb 22, 2022
• Publicly Available Date: Dec 24, 2022
• Publisher: Elsevier
• DOI: https://doi.org/10.1016/j.bbi.2021.12.016
• Keywords: Exercise; Lifestyle; Sedentary behavior; SARS-CoV-2; Coronavirus
• Public URL: https://rgu-repository.worktribe.com/output/1602992
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S0889159121006474?via%3Dihub#m0005
• Related Public URLs: https://rgu-repository.worktribe.com/output/1569327
• Type of Data: Questionnaire, 2 supplementary tables and 4 supplementary figures.
• Collection Date: Dec 9, 2021
• Collection Method: This was a prospective cohort study within an open-label, single-arm, phase 4 vaccination trial. Immunogenicity was assessed after vaccination by measuring seroconversion rates of total anti-SARS-CoV-2 S1/S2 IgG (SC), geometric mean titers of anti-S1/S2 IgG (GMT), factor-increase in GMT (FI-GMT), frequency of neutralizing antibody (NAb), and median neutralizing activity. Physical activity (active being defined as ≥ 150 min/week) and sedentary behavior (>8h/day) were assessed by questionnaire.