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Effect of feeding insoluble fiber on the microbiota and metabolites of the caecum and feces of rabbits recovering from epizootic rabbit enteropathy relative to non-infected rabbits.

Pu�n-Pel�ez, Xiao-Haitzi Daniel; McEwan, Neil Ross; �lvarez-Mart�nez, Roberto Carlos; Mariscal-Land�n, Gerardo; Nava-Morales, Gerardo Manuel; Mosqueda, Juan; Olvera-Ram�rez, Andrea Margarita

Authors

Xiao-Haitzi Daniel Pu�n-Pel�ez

Neil Ross McEwan

Roberto Carlos �lvarez-Mart�nez

Gerardo Mariscal-Land�n

Gerardo Manuel Nava-Morales

Juan Mosqueda

Andrea Margarita Olvera-Ram�rez



Abstract

This study aimed to investigate the effect of feeding insoluble fiber on the microbiota and metabolites of the caecum and feces of rabbits recovering from epizootic rabbit enteropathy relative to non-infected rabbits. Rabbits that had either recovered from epizootic rabbit enteropathy or ones that had never had epizootic rabbit enteropathy were fed on a diet of 32% or 36% neutral detergent fiber until they were 70 days of age. At this point, the short-chain fatty acid and ammonia levels were measured in caecotroph and fecal samples and compared using 2 × 2 ANOVA. The microbial composition of the samples was also analyzed using next-generation sequencing and compared by PERMANOVA. Caecotrophic samples from previously affected rabbits on lower fiber diets had higher short-chain fatty acid contents and higher species diversity index values for some indices (p [less than] 0.05), although the fecal samples showed lower species diversity levels (p [less than] 0.05). In addition, the PERMANOVA analyses demonstrated that differences were detected in the microbial composition of both fecal and caecotrophic samples, depending on the disease status at the outset of the experiment (p [less than] 0.05). The results of this work show that, although there is some potential in the use of high-fiber diets for the treatment of rabbits that have had epizootic rabbit enteropathy, they are not able to produce the same digestive tract properties as those seen in rabbits that have never had the condition. This is true even after the rabbits have recovered from epizootic rabbit enteropathy.

Citation

PUÓN-PELÁEZ, X.-H.D., MCEWAN, N.R., ÁLVAREZ-MARTÍNEZ, R.C., MARISCAL-LANDÍN, G., NAVA-MORALES, G.M., MOSQUEDA, J. and OLVERA-RAMÍREZ, A.M. 2022. Effect of feeding insoluble fiber on the microbiota and metabolites of the caecum and feces of rabbits recovering from epizootic rabbit enteropathy relative to non-infected rabbits. Pathogens [online], 11(5), article 571. Available from: https://doi.org/10.3390/pathogens11050571

Journal Article Type Article
Acceptance Date Apr 20, 2022
Online Publication Date May 12, 2022
Publication Date May 31, 2022
Deposit Date May 13, 2022
Publicly Available Date May 27, 2022
Journal Pathogens
Electronic ISSN 2076-0817
Publisher MDPI
Peer Reviewed Peer Reviewed
Volume 11
Issue 5
Article Number 571
DOI https://doi.org/10.3390/pathogens11050571
Keywords Infectious Diseases; Microbiology (medical); General Immunology and Microbiology; Molecular Biology; Immunology and Allergy
Public URL https://rgu-repository.worktribe.com/output/1664790
Related Public URLs https://rgu-repository.worktribe.com/output/1674814

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