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Effect of feeding insoluble fiber on the microbiota and metabolites of the caecum and feces of rabbits recovering from epizootic rabbit enteropathy relative to non-infected rabbits. [Dataset]


Xiao-Haitzi Daniel Pu�n-Pel�ez
Data Collector

Neil Ross McEwan
Data Collector

Roberto Carlos �lvarez-Mart�nez
Data Collector

Gerardo Mariscal-Land�n
Data Collector

Gerardo Manuel Nava-Morales
Data Collector

Juan Mosqueda
Data Collector

Andrea Margarita Olvera-Ram�rez
Data Collector


Epizootic rabbit enteropathy (ERE) is a digestive disease that has negatively affected international rabbit production since the 1990s, with morbidities of up to 90% and mortalities of 80%. ERE generally affects rabbits aged 3–7 weeks, reducing their daily food intake. A recent review of the factors associated with ERE and how to treat it included the use of elevated fiber levels as one mechanism of treatment. The accompanying file contains supplementary information sequence information.


PUÓN-PELÁEZ, X.-H.D., MCEWAN, N.R., ÁLVAREZ-MARTÍNEZ, R.C., MARISCAL-LANDÍN, G., NAVA-MORALES, G.M., MOSQUEDA, J. and OLVERA-RAMÍREZ, A.M. 2022. Effect of feeding insoluble fiber on the microbiota and metabolites of the caecum and feces of rabbits recovering from epizootic rabbit enteropathy relative to non-infected rabbits. [Dataset]. Pathogens [online], 11(5), article 571. Available from:

Acceptance Date Apr 20, 2022
Online Publication Date May 12, 2022
Publication Date May 31, 2022
Deposit Date May 27, 2022
Publicly Available Date May 27, 2022
Publisher MDPI
Keywords Rabbit; Enteropathy; Epizootic; Fiber; Fermentation
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Related Public URLs
Type of Data XLSX files.
Collection Date Apr 20, 2022
Collection Method The experimental work was carried out at the Amazcala Campus of the College of Natural Sciences, Autonomous University of Queretaro. Sixteen female New Zealand rabbits aged 32 days old were housed as groups of 4 rabbits in American-type cages (90 cm × 60 cm × 40 cm) equipped with feeders and drinking fountains. Rabbits were allocated in a 2 × 2 design experiment, with 4 rabbits per group. All rabbits that had ERE at the outset acquired it spontaneously (i.e., it was not induced) and had not been given any antibiotic treatment for the condition. An ERE diagnosis was confirmed by the first author of this work, who is a qualified veterinary surgeon. At the outset of the experimental work (i.e., when the rabbits were 32 days old), the rabbits were allocated to a group based on either having ERE or being clear of it (deemed healthy) and on a diet of 32% NDF, which is recommended for the intestinal health of the rabbit, or 36% NDF, which has been suggested for the treatment of ERE. Although it was not possible to balance rabbits for weight between the ERE and healthy groups, due to the ERE rabbits being significantly lighter at the outset, the rabbits were balanced as closely as possible for the dietary regimes. The diets were formulated with the same ingredients: alfalfa meal, canola meal, wheat bran, sunflower meal, sodium chloride, calcium carbonate, vitamins, and minerals. No antibiotics or anticoccidial drugs were included in the diet. All rabbits were given ad libitum access to food and water. The experimental groups were designated as follows: T1 = healthy with 32% NDF, T2 = healthy with 36% NDF, T3 = ERE clinical signs with 32% NDF, and T4 = ERE clinical signs with 36% NDF. The presence of diarrhea (an ERE clinical sign) was checked by measuring the severity (0 = no diarrhea, 1 = slight, 2 = moderate, and 3 = severe). At the start of the experimental work, all rabbits categorized as having ERE were around the 1 to 2 boundaries of severity. Information regarding the productivity values that were recorded or measured were: initial weight (IW), weekly weight gain, final weight (FW), food consumption (FC), and daily weight gain (DWG).