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Efficient breast cancer classification network with dual squeeze and excitation in histopathological images.

Sarker, Md. Mostafa Kamal; Akram, Farhan; Alsharid, Mohammad; Singh, Vivek Kumar; Yasrab, Robail; Elyan, Eyad


Md. Mostafa Kamal Sarker

Farhan Akram

Mohammad Alsharid

Vivek Kumar Singh

Robail Yasrab


Medical image analysis methods for mammograms, ultrasound, and magnetic resonance imaging (MRI) cannot provide the underline features on the cellular level to understand the cancer microenvironment which makes them unsuitable for breast cancer subtype classification study. In this paper, we propose a convolutional neural network (CNN)-based breast cancer classification method for hematoxylin and eosin (H&E) whole slide images (WSIs). The proposed method incorporates fused mobile inverted bottleneck convolutions (FMB-Conv) and mobile inverted bottleneck convolutions (MBConv) with a dual squeeze and excitation (DSE) network to accurately classify breast cancer tissue into binary (benign and malignant) and eight subtypes using histopathology images. For that, a pre-trained EfficientNetV2 network is used as a backbone with a modified DSE block that combines the spatial and channel-wise squeeze and excitation layers to highlight important low-level and high-level abstract features. Our method outperformed ResNet101, InceptionResNetV2, and EfficientNetV2 networks on the publicly available BreakHis dataset for the binary and multi-class breast cancer classification in terms of precision, recall, and F1-score on multiple magnification levels.


SARKER, M.M.K., AKRAM, F., ALSHARID, M., SINGH, V.K., YASRAB, R. and ELYAN, E. 2023. Efficient breast cancer classification network with dual squeeze and excitation in histopathological images. Diagnostics [online], 13(1), article 103. Available from:

Journal Article Type Article
Acceptance Date Dec 20, 2022
Online Publication Date Dec 29, 2022
Publication Date Jan 1, 2023
Deposit Date Jan 16, 2023
Publicly Available Date Jan 16, 2023
Journal Diagnostics
Electronic ISSN 2075-4418
Publisher MDPI
Peer Reviewed Peer Reviewed
Volume 13
Issue 1
Article Number 103
Keywords Breast cancer; Histopathology; Convolutional neural network; Dual squeeze; Excitation mechanism
Public URL


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