Phenome-wide association study of genetically predicted B vitamins and homocysteine biomarkers with multiple health and disease outcomes: analysis of the UK Biobank. [Dataset]

Abstract

The aim of this study was to explore the effects of B vitamins and homocysteine on a wide range of health outcomes based on a large biorepository linking biological samples and electronic medical records. Significant nonlinear dose-response relationships were observed for the associations of folate with anemia, vitamin B12 with vitamin B-complex deficiencies, anemia and cholelithiasis, and homocysteine with cerebrovascular disease. This study provides strong evidence for the associations of B vitamins and homocysteine with endocrine/metabolic and genitourinary disorders.

Citation

WANG, L., LI, X., MONTAZERI, A., MACFARLANE, A.J., MOMOLI, F., DUTHIE, S., SENEKAL, M., EGUIAGARAY, I.M., MUNGER, R., BENNETT, D., CAMPBELL, H., RUBINI, M., MCNULTY, H., LITTLE, J. and THEODORATOU, E. 2023. Phenome-wide association study of genetically predicted B vitamins and homocysteine biomarkers with multiple health and disease outcomes: analysis of the UK Biobank. [Dataset]. American journal of clinical nutrition [online], 117(3), pages 564-575. Available from: https://doi.org/10.1016/j.ajcnut.2023.01.005

• Acceptance Date: Jan 9, 2023
• Online Publication Date: Jan 13, 2023
• Publication Date: Mar 31, 2023
• Deposit Date: Jan 13, 2023
• Publicly Available Date: Jan 14, 2024
• Publisher: Elsevier
• DOI: https://doi.org/10.1016/j.ajcnut.2023.01.005
• Keywords: B vitamins; Homocysteine; PheWAS; Mendelian randomization
• Public URL: https://rgu-repository.worktribe.com/output/1854616
• Related Public URLs: https://rgu-repository.worktribe.com/output/1854594
• Type of Data: Supplementary tables and figure.
• Collection Date: Jul 12, 2022
• Collection Method: A phenome-wide association study (PheWAS) to investigate associations of genetically predicted plasma concentrations (genetic component of the circulating concentrations) of folate, vitamin B6, vitamin B12 and their metabolite homocysteine with a wide range of disease outcomes (including both prevalent and incident events) among 385,917 individuals in the UK Biobank. Then a two-sample Mendelian randomization (MR) analysis was used to replicate any observed associations and detect causality. The authors then considered MR p <0.05 as significant for replication. Finally, dose-response, mediation and bioinformatics analyses were carried out to examine any non-linear trends and to disentangle the underlying mediating biological mechanisms for the identified associations.
• Additional Information: Further research was conducted using the UK Biobank Resource under Application Number 10775. Data are available from the UK Biobank ( https://www.ukbiobank.ac.uk/ ), for researchers who meet the criteria and gain approval from the UK Biobank to access the research database.