P1NP and β-CTX-1 responses to a prolonged, continuous running bout in young healthy adult males: a systematic review with individual participant data meta-analysis. [Dataset]

Abstract

Circulating biomarkers of bone formation and resorption are widely used in exercise metabolism research, but their responses to exercise are not clear. To quantify group responses and inter-individual variability of P1NP and β-CTX-1 after prolonged, continuous running (60-120 min at 65-75% VO2max) in young healthy adult males using individual participant data (IPD) meta-analysis. The protocol was designed following PRISMA-IPD guidelines. The accompanying file contains a spreadsheet of data extraction and codebooks and a modified Downs and Black checklist.

Citation

CIVIL, R., DOLAN, E., SWINTON, P.A., SANTOS, L., VARLEY, I., ATHERTON, P.J., ELLIOTT-SALE, K.J. and SALE, C. 2023. P1NP and β-CTX-1 responses to a prolonged, continuous running bout in young healthy adult males: a systematic review with individual participant data meta-analysis. [Dataset]. Sports medicine-open [online], 9, article number 85. Available from: https://sportsmedicine-open.springeropen.com/articles/10.1186/s40798-023-00628-x#Sec27

• Acceptance Date: Aug 12, 2023
• Online Publication Date: Sep 19, 2023
• Publication Date: Dec 31, 2023
• Deposit Date: Sep 29, 2023
• Publicly Available Date: Sep 29, 2023
• Publisher: Springer
• DOI: https://doi.org/10.1186/s40798-023-00628-x
• Keywords: Bone remodelling; Bone markers; Exercise; Running; Inter-individual variability; Proportion of response
• Public URL: https://rgu-repository.worktribe.com/output/2093054
• Related Public URLs: https://rgu-repository.worktribe.com/output/2043733 (Journal article)
• Type of Data: XLSX and DOCX files.
• Collection Date: May 10, 2021
• Collection Method: The protocol for this review included all items described in the checklist of Preferred Reporting Items for Systematic Review and Meta-Analysis of Individual Participant Data (PRISMA-IPD) [20, 21]. The protocol for this review was pre-registered on the Open Science Framework prior to implementation (https://osf.io/y69nd). In the pre-registered protocol, a combined approach of aggregate data and individual participant data meta-analyses was proposed. Because individual participant data were obtained from all running studies, however, the aggregate analysis was deemed unnecessary for the purpose of this investigation. The pre-registered protocol indicated that the statistical model would include the estimation of variability ratio (ratio of standard deviation of inter-individual difference scores relative to measurement error values); this estimation was not included in the statistical approach due to the fact that measurement error values were often as large as variation in the intervention.