A uniquely positive, self-described patient experience with the R-MAOI Moclobemide, prescribed for treatment-resistant-depression-anxiety.

Adams, Nicholas Norman

Abstract

Treatment-resistant clinical depression and linked-anxiety represents a serious debilitating illness. Individual presentation differs. Symptoms can be co-occurring depressive-state and high-anxiety [1], [2]. My own longitudinal experiences with depression-anxiety represent -at times- the above description. I also have a diagnosis of ADHD (diagnosed in childhood, re-diagnosed in adulthood). Over the last twenty-two-plus years, I was prescribed fifteen-plus antidepressant and associated medications, with little lasting positive effect from the SS/SNRIs, TCA and atypical medication families, with adjunctive medications/treatments also added. After a ten-year medication gap; relying on self-implemented coping routines and mechanisms, I felt in late-2022 that I was no longer able to manage recurrent, escalating depression-anxiety sufficiently without immediate pharmacological help. Moclobemide was suggested to me by a past psychiatrist over a decade ago (2012), however then another medication combination was trialled. I began Moclobemide in January 2023, prescribed from a different psychiatrist. This publication explores my experience with the unique positive effects of Moclobemide, drawing distinctions with other medications (and medication-classes) I have previously taken with little long-term positive effects.

Citation

ADAMS, N.N. 2024. A uniquely positive, self-described patient experience with the R-MAOI Moclobemide, prescribed for treatment-resistant-depression-anxiety. Psychiatry research [online], 337, article number 115924. Available from: https://doi.org/10.1016/j.psychres.2024.115924

• Journal Article Type: Letter
• Acceptance Date: Apr 21, 2024
• Online Publication Date: Apr 25, 2024
• Publication Date: Jul 31, 2024
• Deposit Date: Apr 25, 2024
• Publicly Available Date: Apr 26, 2025
• Journal: Psychiatry research
• Print ISSN: 0165-1781
• Electronic ISSN: 1872-7123
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 337
• Article Number: 115924
• DOI: https://doi.org/10.1016/j.psychres.2024.115924
• Keywords: Mental health; Anxiety; Depression; Medication
• Public URL: https://rgu-repository.worktribe.com/output/2308100