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A uniquely positive, self-described patient experience with the R-MAOI Moclobemide, prescribed for treatment-resistant-depression-anxiety.

Adams, Nicholas Norman

Authors



Abstract

Treatment-resistant clinical depression and linked-anxiety represents a serious debilitating illness. Individual presentation differs. Symptoms can be co-occurring depressive-state and high-anxiety [1], [2]. My own longitudinal experiences with depression-anxiety represent -at times- the above description. I also have a diagnosis of ADHD (diagnosed in childhood, re-diagnosed in adulthood). Over the last twenty-two-plus years, I was prescribed fifteen-plus antidepressant and associated medications, with little lasting positive effect from the SS/SNRIs, TCA and atypical medication families, with adjunctive medications/treatments also added. After a ten-year medication gap; relying on self-implemented coping routines and mechanisms, I felt in late-2022 that I was no longer able to manage recurrent, escalating depression-anxiety sufficiently without immediate pharmacological help. Moclobemide was suggested to me by a past psychiatrist over a decade ago (2012), however then another medication combination was trialled. I began Moclobemide in January 2023, prescribed from a different psychiatrist. This publication explores my experience with the unique positive effects of Moclobemide, drawing distinctions with other medications (and medication-classes) I have previously taken with little long-term positive effects.

Citation

ADAMS, N.N. 2024. A uniquely positive, self-described patient experience with the R-MAOI Moclobemide, prescribed for treatment-resistant-depression-anxiety. Psychiatry research [online], 337, article number 115924. Available from: https://doi.org/10.1016/j.psychres.2024.115924

Journal Article Type Letter
Acceptance Date Apr 21, 2024
Online Publication Date Apr 25, 2024
Publication Date Jul 31, 2024
Deposit Date Apr 25, 2024
Publicly Available Date Apr 26, 2025
Journal Psychiatry research
Print ISSN 0165-1781
Electronic ISSN 1872-7123
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 337
Article Number 115924
DOI https://doi.org/10.1016/j.psychres.2024.115924
Keywords Mental health; Anxiety; Depression; Medication
Public URL https://rgu-repository.worktribe.com/output/2308100