Alec Singer
Give it a rest: a systematic review with Bayesian meta-analysis on the effect of inter-set rest interval duration on muscle hypertrophy.
Singer, Alec; Wolf, Milo; Generoso, Leonardo; Arias, Elizabeth; Delcastillo, Kenneth; Echevarria, Edwin; Martinez, Amaris; Korakakis, Patroklos Androulakis; Refalo, Martin C.; Swinton, Paul A.; Schoenfeld, Brad J.
Authors
Milo Wolf
Leonardo Generoso
Elizabeth Arias
Kenneth Delcastillo
Edwin Echevarria
Amaris Martinez
Patroklos Androulakis Korakakis
Martin C. Refalo
Dr Paul Swinton p.swinton@rgu.ac.uk
Associate Professor
Brad J. Schoenfeld
Abstract
We systematically searched the literature for studies with a randomized design that compared different inter-set rest interval durations for estimates of pre-/post-study changes in lean/muscle mass in healthy adults while controlling all other training variables. Meta-analyses on non-controlled effect sizes using hierarchical models of all 19 measurements (thigh: 10; arm: 6; whole body: 3) from 9 studies meeting inclusion criteria analyses showed substantial overlap of standardized mean differences across the different inter-set rest periods (binary: short: 0.48 [95%CrI: 0.19 to 0.81], longer: 0.56 [95%CrI: 0.24 to 0.86]; Four categories: short: 0.47 [95%CrI: 0.19 to 0.80], intermediate: 0.65 [95%CrI: 0.18 to 1.1], long: 0.55 [95%CrI: 0.15 to 0.90], very long: 0.50 [95%CrI: 0.14 to 0.89]), with substantial heterogeneity in results. Univariate and multivariate pairwise meta-analyses of controlled binary (short vs longer) effect sizes showed similar results for the arm and thigh with central estimates tending to favor longer rest periods (arm: 0.13 [95%CrI: -0.27 to 0.51]; thigh: 0.17 [95%CrI: -0.13 to 0.43]). In contrast, central estimates closer to zero but marginally favoring shorter rest periods were estimated for the whole body (whole body: -0.08 [95%CrI: -0.45 to 0.29]). Subanalysis of set end-point data indicated that training to failure or stopping short of failure did not meaningfully influence the interaction between rest interval duration and muscle hypertrophy. In conclusion, results suggest a small hypertrophic benefit to employing inter-set rest interval durations >60 seconds, perhaps mediated by reductions in volume load. However, our analysis did not detect appreciable differences in hypertrophy when resting >90 seconds between sets, consistent with evidence that detrimental effects on volume load tend to plateau beyond this time-frame.
Citation
SINGER, A., WOLF, M., GENEROSO, L., ARIAS, E., DELCASTILLO, K., ECHEVARRIA, E., MARTINEZ, A., KORAKAKIS, P.A., REFALO, M.C., SWINTON, P.A. and SCHOENFELD, B.J. [2024], Give it a rest: a systematic review with Bayesian meta-analysis on the effect of inter-set rest interval duration on muscle hypertrophy. Frontiers in sports and active living [online], (accepted). To be made available from: https://www.frontiersin.org/journals/sports-and-active-living/articles
Journal Article Type | Article |
---|---|
Acceptance Date | May 22, 2024 |
Deposit Date | May 24, 2024 |
Publicly Available Date | May 24, 2024 |
Journal | Frontiers in sports and active living |
Publisher | Frontiers Media |
Peer Reviewed | Peer Reviewed |
Keywords | Rest period; Recovery interval; Muscle growth; Muscle development; Muscle thickness; Muscle cross-sectional area |
Public URL | https://rgu-repository.worktribe.com/output/2344312 |
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SINGER 2024 Give it a rest (AAM)
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Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
Copyright Statement
© 2024 The Authors. The version of record of this article, first published in Frontiers in Sports and Active Living, is available online at Publisher’s website: https://www.frontiersin.org/journals/sports-and-active-living/articles.
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