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Disposable screen printed sensor for the electrochemical detection of methamphetamine in undiluted saliva.

Bartlett, Carrie-Ann; Taylor, Sarah; Fernandez, Carlos; Wanklyn, Ceri; Burton, Daniel; Enston, Emma; Raniczkowska, Aleksandra; Black, Murdo; Murphy, Lindy


Carrie-Ann Bartlett

Sarah Taylor

Ceri Wanklyn

Daniel Burton

Emma Enston

Aleksandra Raniczkowska

Murdo Black

Lindy Murphy


Background: Methamphetamine has an adverse effect on the ability to drive safely. Police need to quickly screen potentially impaired drivers therefore a rapid disposable test for methamphetamine is highly desirable. This is the first proof-of-concept report of a disposable electrochemical test for methamphetamine in undiluted saliva. Results: A screen printed carbon electrode is used for the N,N'-(1,4-phenylene)-dibenzenesulfonamide mediated detection of methamphetamine in saliva buffer and saliva. The oxidized mediator reacts with methamphetamine to give an electrochemically active adduct which can undergo electrochemical reduction. Galvanostatic oxidation in combination with a double square wave reduction technique resulted in detection of methamphetamine in undiluted saliva with a response time of 55 s and lower detection limit of 400 ng/mL. Conclusions: Using a double square wave voltammetry technique, rapid detection of methamphetamine in undiluted saliva can be achieved, however there is significant donor variation in response and the detection limit is significantly higher than desired. Further optimization of the assay and sensor format is required to improve the detection limit and reduce donor effects.


BARTLETT, C.-A., TAYLOR, S., FERNANDEZ, C., WANKLYN, C., BURTON, D., ENSTON, E., RANICZKOWSKA, A., BLACK, M. and MURPHY, L. 2016. Disposable screen printed sensor for the electrochemical detection of methamphetamine in undiluted saliva. Chemistry central journal [online], 10, article number 3. Available from:

Journal Article Type Article
Acceptance Date Jan 7, 2016
Online Publication Date Feb 1, 2016
Publication Date Dec 31, 2016
Deposit Date Apr 19, 2016
Publicly Available Date Apr 19, 2016
Journal Chemistry central journal
Electronic ISSN 1752-153X
Publisher Springer
Peer Reviewed Peer Reviewed
Volume 10
Article Number 3
Keywords Square wave voltammetry (SWV); Galvanostatic oxidation; Screen printed electrode; Mediator; Methamphetamine; Saliva; Detection
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