Skip to main content

Research Repository

See what's under the surface

Evaluation of new naphthalimides as potential anticancer agents against breast cancer MCF-7, pancreatic cancer BxPC-3 and colon cancer HCT-15 cell lines.

Noro, J.; Maciel, J.; Duarte, D.; Olival, A.C.D.; Baptista, C.; Silva, A.C.D.; Alves, M.J.; Lin, P. Kong Thoo

Authors

J. Noro

J. Maciel

D. Duarte

A.C.D. Olival

C. Baptista

A.C.D. Silva

M.J. Alves

P. Kong Thoo Lin



Abstract

New 1,8-naphthalimido derivatives with 2,3 and 4 carbon chains bearing a number of different functionalities were synthesized and tested against a panel of breast cancer MCF-7, colon cancer HCT-15 and pancreatic cancer BxPC-3 cell lines. Generally structures with shorter alkyl chains were more active, with the one exception of the amide containing a p-nitrophenyl group. GI50 values (uM) were determined for the most active compounds. Three compounds exhibited GI50 values below 5 uM, two with MCF-7 cells, and one other with HCT-15. Compounds with different functionalities demonstrated cell line specificity: the MCF-7 cell line was more sensitive to an urea derivative (6f), the growth of HCT- 15 cells were most affected by a triazole (9d), while the BxPC-3 cell line was inhibited in a higher extend by a guanidine (4a).

Journal Article Type Article
Publication Date Jul 20, 2015
Journal Organic chemistry: current research
Electronic ISSN 2161-0401
Publisher New Publisher Required
Peer Reviewed Peer Reviewed
Volume 4
Issue 3
Article Number 1000144
Institution Citation NORO, J., MACIEL, J., DUARTE, D., OLIVAL, A.C.D., BAPTISTA, C., SILVA, A.C.D., ALVES, M.J. and KONG THOO LIN, P. 2015. Evaluation of new naphthalimides as potential anticancer agents against breast cancer MCF-7, pancreatic cancer BxPC-3 and colon cancer HCT-15 cell lines. Organic chemistry: current research [online], 4(3), ID 1000144. Available from: https://doi.org/10.4172/2161-0401.1000144
DOI https://doi.org/10.4172/2161-0401.1000144
Keywords Toxicity; Tetrabromide; Naphthalimide; Isocyanate; Membrane permeabilisation

Files







Downloadable Citations