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Valorisation of whisky distillery waste as a sustainable source of antioxidant and antibacterial properties with neuroprotective potential.

Blaikie, Laura; Welgamage Don, Aakash; Franzen, Xenia; Fernandez, Carlos; Faisal, Nadimul; Kong Thoo Lin, Paul

Authors

Laura Blaikie

Xenia Franzen



Abstract

Waste by-products such as pot ale are abundantly produced during the whisky distillation process and are conventionally used as livestock feed, however a significant proportion continues to require land and sea disposal. Here, the novel potential of whisky by-products as antioxidant and antibacterial agents was investigated. The use of natural products as antioxidants and antimicrobials is widely popular in medicine, and the recovery of bioactive compounds from waste is increasingly important to improve environmental sustainability. Pot ale demonstrated the strongest antioxidant activity of the by-products tested and could reduce DNA damage by 52% at 0.5 mg/mL. Furthermore, pot ale was non-toxic in a neuroblastoma cell line up to 5 mg/mL and protected against the toxic effects of two inducers of oxidative stress (rotenone and hydrogen peroxide) by up to 1.25-fold. Pot ale also showed potent antibacterial activity against Escherichia coli and Staphylococcus aureus with the minimum inhibitory concentration of 25 μg/mL and 1.56 μg/mL respectively. This work provides the first evidence of the potential of whisky by-products as antioxidants and antimicrobials with no adverse effects in cells, thereby promoting a circular economy

Citation

BLAIKIE, L., WELGAMAGE DON, A., FRANZEN, X., FERNANDEZ, C., FAISAL, N. and KONG THOO LIN, P. [2023]. Valorisation of whisky distillery waste as a sustainable source of antioxidant and antibacterial properties with neuroprotective potential. Waste and biomass valorization [online], Online First. Available from: https://doi.org/10.1007/s12649-023-02292-4

Journal Article Type Article
Acceptance Date Sep 24, 2023
Online Publication Date Oct 24, 2023
Deposit Date Oct 17, 2023
Publicly Available Date Oct 17, 2023
Journal Waste and biomass valorization
Print ISSN 1877-2641
Electronic ISSN 1877-265X
Publisher Springer
Peer Reviewed Peer Reviewed
DOI https://doi.org/10.1007/s12649-023-02292-4
Keywords Whisky-waste; Valorisation; Antioxidant-antibacterial; Pot ale
Public URL https://rgu-repository.worktribe.com/output/2085337
Additional Information The preprint of this article is held online: BLAIKEIE, L., WELGAMAGE, A., FRANZEN, X., FERNANDEZ, C., FAISAL, N. and KONG THOO LIN, P. 2023. Valorisation of whisky distillery waste as a sustainable source of antioxidant and antibacterial properties with neuroprotective potential. Hosted on SSRN [online]. Available from: http://dx.doi.org/10.2139/ssrn.4373171

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