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Differential pulse voltammetric determination of albendazole and mebendazole in pharmaceutical formulations based on modified sonogel carbon paste electrodes with perovskite-type LaFeO3 nanoparticles.

Lopes de Macedo, Isaac Yves; Garcia, Luane Ferreira; Souza, Aparecido Ribeiro de; Silva, Adélia Maria Lima da; Fernandez, Carlos; Santos, Maycon Dible Gonçalves; Magalhães, River Souza; Torres, Ieda Maria Sapateiro; Gil, Eric de Souza

Authors

Isaac Yves Lopes de Macedo

Luane Ferreira Garcia

Aparecido Ribeiro de Souza

Adélia Maria Lima da Silva

Carlos Fernandez

Maycon Dible Gonçalves Santos

River Souza Magalhães

Ieda Maria Sapateiro Torres

Eric de Souza Gil



Abstract

Benzimidazoles, such as albendazole (AB) and mebendazole (MB), are common anthelmintic agents, widely used throughout the world to combat parasitic diseases. The electroanalytical sensing of AB and MB based on Perovskite-Type LaFeO3 nanoparticles modified sonogel carbon paste electrodes has been reported for the first time. Perovskite-type LaFeO3 nanoparticles were characterized by X-ray diffraction (XRD), fourier transform infrared (FTIR), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The XRD indicates the formation of monophase perovskite LaFeO3 and FT-IR spectrum shows a band at 570 cm?1 which is associated to the formation of lanthanum ferrite. Microscopy images show that the distribution in pore size and shape is not well defined. The particles sizes are found to be above 200 nm. It was found that sonogel carbon paste modified electrodes with Perovskite-type LaFeO3 nanoparticles exhibit higher catalytic activity and sensitivity toward the detection of AB and MB compared to the unmodified electrode. The limits of detection for albendazole and mebendazole were reported to be 0.3 'M and 0.6 'M respectively and the limits of quantification 0.8 'M and 1.7 'M respectively. The electroanalytical protocol was successfully applied for the sensing of AB and MB in pharmaceutical formulations.

Journal Article Type Article
Publication Date May 27, 2016
Journal Journal of the Electrochemical Society
Print ISSN 0013-4651
Electronic ISSN 1945-7111
Publisher Electrochemical Society
Peer Reviewed Peer Reviewed
Volume 163
Issue 8
Pages B428-B434
Institution Citation LOPES DE MACEDO, I.Y., FERREIRA GARCIA, L., RIBEIRO DE SOUZA, A., LIMA DA SILVA, A.M., FERNANDEZ, C., GONÇALVES SANTOS, M.D., SOUZA MAGALHÃES, R., SAPATEIRO TORRES, I.M. and DE SOUZA GIL, E. 2016. Differential pulse voltammetric determination of albendazole and mebendazole in pharmaceutical formulations based on modified sonogel carbon paste electrodes with perovskite-type LaFeO3 nanoparticles. Journal of the Electrochemical Society [online], 163(8), pages B428-B434. Available from: https://doi.org/10.1149/2.0661608jes
DOI https://doi.org/10.1149/2.0661608jes
Keywords Albendazole; Benzimidazoles; Mebendazole; Nanoparticles; Perovskite; Pharmaceutical analysis; Sensors; Sonogel; Voltammetry

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