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Nutritional and methodological perspectives of zinc ions and complexes: physiological and pathological states.

Molina-L�pez, Jorge; Planells del Pozo, Elena; Florea, Daniela Ioana; Fernandez, Carlos; Osso, Bartolome Quintero; Zalewska, Marta; Krizkova, Sona; Heger, Zbynek; Kizek, Rene; Adam, Vojtech


Jorge Molina-L�pez

Elena Planells del Pozo

Daniela Ioana Florea

Bartolome Quintero Osso

Marta Zalewska

Sona Krizkova

Zbynek Heger

Rene Kizek

Vojtech Adam


Zinc, an essential element playing crucial roles in numerous physiological, but also pathological processes, is still one of the most studied elements. The main importance of this metal is especially based on the structural role of zinc ions in many proteins including the transcription factors, antioxidant enzymes, and metallothioneins. Due to the role of zinc in many crucial physiological processes, its homeostasis must be intensively controlled. The controlling mechanisms are based especially on the zinc transporters and low-molecular proteins metallothioneins (MT). Zinc deficiency has been related with different state of diseases. Here, we primarily aim our attention to zinc and nutrition reviewing the whole process from intake to determination of this metal. The function of zinc ions in proteins with particular emphasis to oxidative stress is discussed followed by intake mechanisms and the role of zinc ions in both physiological and pathological processes. Finally, we summarized the assays used for detection of zinc in complex biological matrices.


MOLINA-LOPEZ, J., PLANELLS DEL POZO, E., FLOREA, D.L., FERNANDEZ, C., OSSO, B.Q., ZALEWSKA, M., KRIZKOVA, S., HEGER, Z., KIZEK, R. and ADAM, V. 2016. Nutritional and methodological perspectives of zinc ions and complexes: physiological and pathological states. International journal of electrochemical science [online], 11(6), pages 4470-4496. Available from:

Journal Article Type Article
Acceptance Date Apr 3, 2016
Online Publication Date May 4, 2016
Publication Date Jun 30, 2016
Deposit Date Aug 26, 2016
Publicly Available Date Aug 26, 2016
Journal International journal of electrochemical science
Electronic ISSN 1452-3981
Publisher Electrochemical Science Group
Peer Reviewed Peer Reviewed
Volume 11
Issue 6
Pages 4470-4496
Keywords Zinc; Biomaker; Nutrition; Health; Disease; Metallothionein; Spectroscopy
Public URL


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