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High yielding microbubble production method.

Fiabane, Joe; Prentice, Paul; Pancholi, Ketan


Joe Fiabane

Paul Prentice


Microfluidic approaches to microbubble production are generally disadvantaged by low yield and high susceptibility to (micro)channel blockages. This paper presents an alternative method of producing microbubbles of 2.6 m mean diameter at concentrations in excess of 30 × 106 mL-1. In this method, the nitrogen gas flowing inside the liquid jet is disintegrated into spray of microbubble when air surrounding this coflowing nitrogen gas-liquid jet passes through a 100 m orifice at high velocity. Resulting microbubble foam has the polydispersity index of 16%. Moreover, a ratio of mean microbubble diameter to channel width ratio was found to be less than 0.025, which substantially alleviates the occurrence of blockages during production.


FIABANE, J., PRENTICE, P. and PANCHOLI, K. 2016. High yielding microbubble production method. BioMed research international [online], article ID 3572827. Available from:

Journal Article Type Article
Acceptance Date Jan 21, 2016
Online Publication Date Feb 29, 2016
Publication Date Dec 31, 2016
Deposit Date Sep 8, 2016
Publicly Available Date Sep 8, 2016
Journal BioMed research international
Print ISSN 2314-6133
Electronic ISSN 2314-6141
Publisher Hindawi
Peer Reviewed Peer Reviewed
Article Number 3572827
Keywords Microbubble production; Nitrogen gas; Drug delivery; Microfluidic
Public URL


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