High yielding microbubble production method.

Fiabane, Joe; Prentice, Paul; Pancholi, Ketan

Abstract

Microfluidic approaches to microbubble production are generally disadvantaged by low yield and high susceptibility to (micro)channel blockages. This paper presents an alternative method of producing microbubbles of 2.6 m mean diameter at concentrations in excess of 30 × 106 mL-1. In this method, the nitrogen gas flowing inside the liquid jet is disintegrated into spray of microbubble when air surrounding this coflowing nitrogen gas-liquid jet passes through a 100 m orifice at high velocity. Resulting microbubble foam has the polydispersity index of 16%. Moreover, a ratio of mean microbubble diameter to channel width ratio was found to be less than 0.025, which substantially alleviates the occurrence of blockages during production.

Citation

FIABANE, J., PRENTICE, P. and PANCHOLI, K. 2016. High yielding microbubble production method. BioMed research international [online], article ID 3572827. Available from: https://doi.org/10.1155/2016/3572827

• Journal Article Type: Article
• Acceptance Date: Jan 21, 2016
• Online Publication Date: Feb 29, 2016
• Publication Date: Dec 31, 2016
• Deposit Date: Sep 8, 2016
• Publicly Available Date: Sep 8, 2016
• Journal: BioMed research international
• Print ISSN: 2314-6133
• Electronic ISSN: 2314-6141
• Publisher: Hindawi Publishing Corporation
• Peer Reviewed: Peer Reviewed
• Article Number: 3572827
• DOI: https://doi.org/10.1155/2016/3572827
• Keywords: Microbubble production; Nitrogen gas; Drug delivery; Microfluidic
• Public URL: http://hdl.handle.net/10059/1620