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Deferiprone, a non-toxic reagent for determination of iron in samples via sequential injection analysis.

Pragourpun, Kraivinee; Sakee, Uthai; Fernandez, Carlos; Kruanetr, Senee

Authors

Kraivinee Pragourpun

Uthai Sakee

Senee Kruanetr



Abstract

We present for the first time the use of deferiprone as a non-toxic complexing agent for the determination of iron by sequential injection analysis in pharmaceuticals and food samples. The method was based on the reaction of Fe(III) and deferiprone in phosphate buffer at pH 7.5 to give a Fe(III)-deferiprone complex, which showed a maximum absorption at 460 nm. Under the optimum conditions, the linearity range for iron determination was found over the range of 0.05-3.0 μg mL-1 with a correlation coefficient (r2) of 0.9993. The limit of detection and limit of quantitation were 0.032 μg mL-1 and 0.055 μg mL-1, respectively. The relative standard deviation (%RSD) of the method was less than 5.0% (n = 11), and the percentage recovery was found in the range of 96.0-104.0%. The proposed method was satisfactorily applied for the determination of Fe(III) in pharmaceuticals, water and food samples with a sampling rate of 60 h-1.

Citation

PRAGOURPUN, K., SAKEE, U., FERNANDEZ, C. and KRUANETR, S. 2015. Deferiprone, a non-toxic reagent for determination of iron in samples via sequential injection analysis. Spectrochimica acta, part A: molecular and biomolecular spectroscopy [online], 142, pages 110-117. Available from: https://doi.org/10.1016/j.saa.2015.01.081

Journal Article Type Article
Acceptance Date Jan 29, 2015
Online Publication Date Feb 9, 2015
Publication Date May 5, 2015
Deposit Date Sep 15, 2016
Publicly Available Date Sep 15, 2016
Journal Spectrochimica acta, part A: molecular and biomolecular spectroscopy
Print ISSN 1386-1425
Electronic ISSN 1873-3557
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 142
Pages 110-117
DOI https://doi.org/10.1016/j.saa.2015.01.081
Keywords Deferiprone; Iron; Sequential injection
Public URL http://hdl.handle.net/10059/1716
Contract Date Sep 15, 2016