Research Repository

See what's under the surface

Deferiprone, a non-toxic reagent for determination of iron in samples via sequential injection analysis.

Pragourpun, Kraivinee; Sakee, Uthai; Fernandez, Carlos; Kruanetra, Senee

Authors

Kraivinee Pragourpun

Uthai Sakee

Carlos Fernandez

Senee Kruanetra

Abstract

We present for the first time the use of deferiprone as a non-toxic complexing agent for the determination of iron by sequential injection analysis in pharmaceuticals and food samples. The method was based on the reaction of Fe(III) and deferiprone in phosphate buffer at pH 7.5 to give a Fe(III) and deferiprone complex, which showed a maximum absorption at 460 nm. Under the optimum conditions, the linearity range for iron determination was found over the range of 0.05-3.0 microgram per millilitre with a correlation coefficient (r2) of 0.9993. The limit of detection and limit of quantitation were 0.032 microgram per millilitre and 0.055 microgram per millilitre, respectively. The relative standard deviation (%RSD) of the method was less than 5.0% (n = 11), and the percentage recovery was found in the range of 96.0-104.0%. The proposed method was satisfactorily applied for the determination of Fe(III) in pharmaceuticals, water and food samples with a sampling rate of 60 h-1.

Journal Article Type Article
Publication Date May 5, 2015
Journal Spectrochimica acta, part A: molecular and biomolecular spectroscopy
Print ISSN 1386-1425
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 142
Pages 110-117
Institution Citation PRAGOURPUN, K., SAKEE, U., FERNANDEZ, C. and KRUANETR, S. 2015. Deferiprone, a non-toxic reagent for determination of iron in samples via sequential injection analysis. Spectrochimica acta, part A: molecular and biomolecular spectroscopy [online], 142, pages 110-117. Available from: https://doi.org/10.1016/j.saa.2015.01.081
DOI https://doi.org/10.1016/j.saa.2015.01.081
Keywords Deferiprone; Iron; Sequential injection

Files




Downloadable Citations