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Thermally triggered theranostics for pancreatic cancer therapy.

Malekigorji, Maryam; Alfahad, Mohanad; Lin, Paul Kong Thoo; Jones, Stefanie; Curtis, Anthony; Hoskins, Clare

Authors

Maryam Malekigorji

Mohanad Alfahad

Paul Kong Thoo Lin

Stefanie Jones

Anthony Curtis

Clare Hoskins



Abstract

Hybrid iron oxide-gold nanoparticles (HNPs) are capable of drug binding onto their surface with a triggered release at elevated temperatures. The iron oxide core allows for diagnostic imaging whilst heating of the gold shell upon laser irradiation reverses drug binding. This study exploits the reversible binding of novel polyamine based drugs in order to provide specific and effective method for pancreatic cancer treatment. Here we used novel bisnaphthalamido (BNIP) based drug series. Our hybrid nanoparticles (50 nm) were capable of drug loading onto their surface (3:1:0.25, Drug:Fe:Au). By exploiting the surface-to-drug electrostatic interaction of a range of BNIP agents, heat triggered drug release was achieved. 12-fold reduction in IC50 after 24 h in vitro and 5-fold reduction of tumour retardation in vivo compared with free drug in pancreatic models after treatment with the HNP-formulation and laser irradiation. This heat activated system could provide a key platform for future therapy strategies.

Journal Article Type Article
Publication Date Sep 14, 2017
Journal Nanoscale
Print ISSN 2040-3364
Electronic ISSN 2040-3372
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 9
Issue 34
Pages 12735-12745
Institution Citation MALEKIGORJI, M., ALFAHAD, M., KONG THOO LIN, P., JONES, S., CURTIS, A. and HOSKINS, C. 2017. Thermally triggered theranostics for pancreatic cancer therapy. Nanoscale [online], 9(34), pages 12735-12745. Available from: https://doi.org/10.1039/c7nr02751f
DOI https://doi.org/10.1039/c7nr02751f
Keywords Theranostic; Pancreatic cancer; Thermoresponsive drug delivery; Laser irradiation

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