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A summary of new findings on the biological effects of selenium in selected animal species: a critical review.

Hosnedlova, Bozena; Kepinska, Marta; Skalickova, Sylvie; Fernandez, Carlos; Ruttkay-Nedecky, Branislav; Malevu, Thembinkosi Donald; Sochor, Jiri; Baron, Mojmir; Melcova, Magdalena; Zidkova, Jarmila; Kizek, Rene


Bozena Hosnedlova

Marta Kepinska

Sylvie Skalickova

Branislav Ruttkay-Nedecky

Thembinkosi Donald Malevu

Jiri Sochor

Mojmir Baron

Magdalena Melcova

Jarmila Zidkova

Rene Kizek


Selenium is an essential trace element important for many physiological processes, especially for the functions of immune and reproductive systems, metabolism of thyroid hormones, as well as antioxidant defense. Selenium deficiency is usually manifested by an increased incidence of retention of placenta, metritis, mastitis, aborts, lowering fertility and increased susceptibility to infections. In calves, lambs and kids, the selenium deficiency demonstrates by WMD (white muscle disease), in foals and donkey foals, it is associated with incidence of WMD and yellow fat disease, and in pigs it causes VESD (vitamin E/selenium deficiency) syndrome. The prevention of these health disorders can be achieved by an adequate selenium supplementation to the diet. The review summarizes the survey of knowledge on selenium, its biological significance in the organism, the impact of its deficiency in mammalian livestock (comparison of ruminants vs. non-ruminants, herbivore vs. omnivore) and possibilities of its peroral administration. The databases employed were as follows: Web of Science, PubMed, MEDLINE and Google Scholar.


HOSNEDLOVA, B., KEPINSKA, M., SKALICKOVA, S., FERNANDEZ, C., RUTTKAY-NEDECKY, B., MALEVU, T.D., SOCHOR, J., BARON, M., MELCOVA, M., ZIDKOVA, J. and KIZEK, R. 2017. A summary of new findings on the biological effects of selenium in selected animal species: a critical review. International journal of molecular sciences [online], 18(10), paper ID 2209. Available from:

Journal Article Type Article
Acceptance Date Oct 11, 2017
Online Publication Date Oct 21, 2017
Publication Date Oct 31, 2017
Deposit Date Nov 2, 2017
Publicly Available Date Nov 2, 2017
Journal International journal of molecular sciences
Print ISSN 1661-6596
Electronic ISSN 1422-0067
Publisher MDPI
Peer Reviewed Peer Reviewed
Volume 18
Issue 10
Article Number 2209
Keywords Selenium; Antioxidant; Oxidative stress; Ruminants; Horses; Donkeys; Metallomics
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