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Influence of adipose tissue mass on bone mass in an overweight or obese population: systematic review and meta-analysis.

Dolan, Eimear; Swinton, Paul A.; Sale, Craig; Healy, Aoife; O'Reilly, John

Authors

Eimear Dolan

Paul A. Swinton

Craig Sale

Aoife Healy

John O'Reilly



Abstract

Context: The scientific literature shows conflicting evidence about the relationship between adiposity and bone mass in overweight and obese populations. Objective: The aim of this review was to quantify the correlation between adipose mass (absolute and relative) and bone mineral density (BMD) in overweight and obese populations. Data Sources: Three databases were searched electronically. In addition, reference lists of relevant articles were screened. Study Selection: A total of 16 studies, comprising 2587 participants and 75 correlation coefficients were selected for inclusion in the review. Data Extraction: Data were extracted from each study using a standardized form. Results: Multilevel modeling indicated opposing relationships between BMD and adiposity: absolute adiposity correlated positively, and relative adiposity negatively, with BMD. Sex and age were the primary moderators of these relationships. Strong evidence supported a negative relationship between relative adipose mass and BMD in men (R=-0.37; 95%CI, -0.57 to -0.12) and in those aged less than 25 years (R=-0.28; 95%CI, -0.45 to -0.08). Conclusion: To prevent bone loss in overweight and obese populations, nutrition- and exercise-based interventions that focus on a controlled reduction of adipose mass with concomitant preservation of lean mass are recommended. Systematic Review Registration: PROSPERO no. CRD42015024313. Please note that the title given on this manuscript Does adipose tissue mass positively or negatively influence bone mass in an overweight or obese population? A systematic review and meta-analysis. differs from the published version.

Journal Article Type Review
Publication Date Oct 1, 2017
Journal Nutrition reviews
Print ISSN 0029-6643
Electronic ISSN 1753-4887
Publisher Oxford University Press (OUP)
Peer Reviewed Peer Reviewed
Volume 75
Issue 10
Pages 858-870
Institution Citation DOLAN, E., SWNTON, P.A., SALE, C., HEALY, A. and O'REILLY, J. 2017. Influence of adipose tissue mass on bone mass in an overweight or obese population: systematic review and meta-analysis. Nutrition reviews [online], 75(10), pagers 858-870. Available from: https://doi.org/10.1093/nutrit/nux046
DOI https://doi.org/10.1093/nutrit/nux046
Keywords Adiposity; Body composition; Bone mass; Chronic condition; Obesity; Osteoporosis; Nutrition
Related Public URLs http://hdl.handle.net/10059/2806
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