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Influence of adipose tissue mass on bone mass in an overweight or obese population: systematic review and meta-analysis.

Dolan, Eimear; Swinton, Paul A.; Sale, Craig; Healy, Aoife; O'Reilly, John


Eimear Dolan

Craig Sale

Aoife Healy

John O'Reilly


Context: The scientific literature shows conflicting evidence about the relationship between adiposity and bone mass in overweight and obese populations. Objective: The aim of this review was to quantify the correlation between adipose mass (absolute and relative) and bone mineral density (BMD) in overweight and obese populations. Data Sources: Three databases were searched electronically. In addition, reference lists of relevant articles were screened. Study Selection: A total of 16 studies, comprising 2587 participants and 75 correlation coefficients were selected for inclusion in the review. Data Extraction: Data were extracted from each study using a standardized form. Results: Multilevel modeling indicated opposing relationships between BMD and adiposity: absolute adiposity correlated positively, and relative adiposity negatively, with BMD. Sex and age were the primary moderators of these relationships. Strong evidence supported a negative relationship between relative adipose mass and BMD in men (R=-0.37; 95%CI, -0.57 to -0.12) and in those aged less than 25 years (R=-0.28; 95%CI, -0.45 to -0.08). Conclusion: To prevent bone loss in overweight and obese populations, nutrition- and exercise-based interventions that focus on a controlled reduction of adipose mass with concomitant preservation of lean mass are recommended. Systematic Review Registration: PROSPERO no. CRD42015024313. Please note that the title given on this manuscript Does adipose tissue mass positively or negatively influence bone mass in an overweight or obese population? A systematic review and meta-analysis. differs from the published version.


DOLAN, E., SWNTON, P.A., SALE, C., HEALY, A. and O'REILLY, J. 2017. Influence of adipose tissue mass on bone mass in an overweight or obese population: systematic review and meta-analysis. Nutrition reviews [online], 75(10), pagers 858-870. Available from:

Journal Article Type Review
Acceptance Date Sep 28, 2017
Online Publication Date Sep 28, 2017
Publication Date Oct 1, 2017
Deposit Date Nov 21, 2017
Publicly Available Date Sep 29, 2018
Journal Nutrition reviews
Print ISSN 0029-6643
Electronic ISSN 1753-4887
Publisher Oxford University Press
Peer Reviewed Peer Reviewed
Volume 75
Issue 10
Pages 858-870
Keywords Adiposity; Body composition; Bone mass; Chronic condition; Obesity; Osteoporosis; Nutrition
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