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Can selenium supplementation modify oxidative stress in-vitro?

Leighton, Dean; Goua, Marie; Dolan, Eimear; Burgess, Katherine; Bermano, Giovanna

Authors

Dean Leighton

Eimear Dolan



Abstract

Two thirds of the UK population are either overweight or obese (body mass index (BMI) 25-29.9 and >30 kg/m2 respectively) and are typically characterised by systemic oxidative stress (OS); deemed to play a key role in cardiovascular disease (CVD) development. OS results from chronically high reactive oxidative species (ROS) formation and reduced antioxidant status. OS plays a key role in CVD development by initiating atherosclerosis (fatty plaque accumulation within the arterial walls); therefore obese individuals are at increased risk of atherosclerosis development. Increased monocyte ROS generation instigates atherosclerotic plaque formation by increasing the recruitment, binding and transmigration of monocytes across arterial endothelial cells and into the arterial wall. An increased dietary antioxidant intake or up-regulation of endogenous antioxidant enzymes may counteract this OS state and therefore lower CVD risk. Selenium is an essential dietary micronutrient incorporated within the catalytic site of endogenous antioxidant Glutathione Peroxidase (GPx) enzymes, which protect cells from OS and consequent cell damage. There is, however, a lack of knowledge concerning the effect of selenium supplementation in an OS state representative of sedentary overweight/obese individuals. The aim of this work was to investigate the ability of selenium supplementation to modify monocyte cell viability/ROS production under OS. ITEM WAS A POSTER PRESENTATION AT 1ST ANNUAL MEETING OF THE SCOTTISH SOCIETY OF CYTOMICS (SCC) 2014. TRANSLATIONAL CYTOMETRY FROM BENCH TO BEDSIDE

Citation

LEIGHTON, D., GOUA, M., DOLAN, E., BURGESS, K. and BERMANO, G. 2015. Can selenium supplementation modify oxidative stress in-vitro? A role for selenium supplementation in the prevention of cardiovascular disease. Journal of inflammation [online], 12(Supplement 1): abstracts from the 1st Annual meeting of the Scottish Society of Cytomics (SCC), 25 September 2014, Aberdeen, UK, article P7. Available from: https://doi.org/10.1186/1476-9255-12-S1-P7

Journal Article Type Meeting Abstract
Conference Name 1st annual meeting of the Scottish Society of Cytomics (SCC)
Start Date Sep 25, 2014
End Date Sep 25, 2014
Acceptance Date Sep 25, 2014
Online Publication Date Apr 16, 2015
Publication Date Apr 30, 2015
Deposit Date Jun 8, 2015
Publicly Available Date Jun 8, 2015
Journal Journal of inflammation
Print ISSN 1476-9255
Electronic ISSN 1476-9255
Publisher Springer
Peer Reviewed Peer Reviewed
Volume 12
Issue Supplement 1
Article Number P7
Keywords Selenite; U937 cell; Paraquat; Oxidative stress state; Selenium supplementation
Public URL http://hdl.handle.net/10059/1213
Publisher URL http://www.journal-inflammation.com/content/12/S1/P7