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Carbon nanomaterials for targeted cancer therapy drugs: a critical review.

Hosnedlova, Bozena; Kepinska, Marta; Fernandez, Carlos; Peng, Qiuming; Ruttkay-Nedecky, Branislav; Milnerowicz, Halina; Kizek, Rene

Authors

Bozena Hosnedlova

Marta Kepinska

Qiuming Peng

Branislav Ruttkay-Nedecky

Halina Milnerowicz

Rene Kizek



Abstract

Cancer represents one of the main causes of human death in developed countries. Most current therapies, unfortunately, carry a number of side effects, such as toxicity and damage to healthy cells, as well as the risk of resistance and recurrence. Therefore, cancer research is trying to develop therapeutic procedures with minimal negative consequences. The use of nanomaterial-based systems appears to be one of them. In recent years, great progress has been made in the field of possible use of nanomaterials with high potential in biomedical applications. Carbon nanomaterials, thanks to their unique physicochemical properties, are gaining more and more popularity in cancer therapy. They are valued especially for their ability to deliver drugs or small therapeutic molecules to these cells. Through surface functionalization, they can specifically target tumor tissues, increasing the therapeutic potential and significantly reducing the adverse effects of therapy. Their potential future use could, therefore, as vehicles for drug delivery. This review presents the latest findings of research studies using carbon nanomaterials in the treatment of various types of cancer. To carry out this study, different databases such as Web of Science, PubMed, MEDLINE and Google Scholar were employed. The findings of research studies chosen from more than 2000 viewed scientific publications from the last 15 years were compared.

Citation

HOSNEDLOVA, B., KEPINSKA, M., FERNANDEZ, C., PENG, Q., RUTTKAY-NEDECKY, B., MILNEROWICZ, H. and KIZEK, R. 2019. Carbon nanomaterials for targeted cancer therapy drugs: a critical review. Chemical record [online], 19(2-3), pages 502-522. Available from: https://doi.org/10.1002/tcr.201800038

Journal Article Type Article
Acceptance Date Jul 17, 2018
Online Publication Date Aug 29, 2018
Publication Date Feb 28, 2019
Deposit Date Aug 31, 2018
Publicly Available Date Aug 30, 2019
Journal Chemical record
Print ISSN 1527-8999
Electronic ISSN 1528-0691
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 19
Issue 2-3
Pages 502-522
DOI https://doi.org/10.1002/tcr.201800038
Keywords Cancer; Therapy; Carbon nanomaterials; Biomedical applications; Nanomedicine
Public URL http://hdl.handle.net/10059/3099