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Interaction of NKX3.1 and SELENOP genotype with prostate cancer recurrence.

Donadio, Janaina L.S.; Liu, Li; Freeman, Vincent L.; Ekoue, Dede N.; Diamond, Alan M.; Bermano, Giovanna

Authors

Janaina L.S. Donadio

Li Liu

Vincent L. Freeman

Dede N. Ekoue

Alan M. Diamond

Giovanna Bermano



Abstract

Background: NKX3.1 is a tumor suppressor frequently lost in prostate cancer. Previous studies by others indicated that the risks associated with reduced NKX3.1 levels can be enhanced by anti-oxidant supplementation. Selenium is an essential component of several proteins with anti-oxidant functions and lower levels of selenium have been associated with greater risk of prostate cancer. In contrast, participants of the select prostate cancer prevention trial were at increased risk of prostate cancer when supplemented with selenium when their baseline selenium levels were high. Methods: In order to investigate whether there was an interaction between a functional polymorphism in NKX3.1 that results in less protein and selenium status with prostate cancer grade or outcome, plasma selenium levels and the genotypes of NKX3.1 and the selenium carrier protein SELENOP were determined from a cohort of men who underwent radical protatectomy. Results: NKX3.1 and SELENOP genotypes were associated with a more aggressive prostate tumor grade at the time of prostatectomy, but there were no significant interactions of NKX3.1 genotype with either selenium status or SELENOP genotype. There was also a significant association between NKX3.1 genotype and prostate cancer recurrence, however this association was modified by SELENOP genotype, but not with plasma selenium levels. Conclusions: These data indicate that the impact of selenium status on prostate cancer may be influenced by factors other than the amount of selenium in circulation. Please note that the title of this document, 'Deinteraction of NKX3.1 and SELENOP genotype with prostate cancer recurrence', differs slightly from the published version.

Citation

DONADIO, J.L.S., LIU, L., FREEMAN, V.L., EKOUE, D.N., DIAMOND, A.M. and BERMANO, G. 2018. Interaction of NKX3.1 and SELENOP genotype with prostate cancer recurrence. Prostate [online], 79(5), pages 462-467. Available from: https://doi.org/10.1002/pros.23752

Journal Article Type Article
Acceptance Date Nov 27, 2018
Online Publication Date Dec 23, 2018
Publication Date Apr 1, 2019
Deposit Date Feb 21, 2019
Publicly Available Date Dec 24, 2019
Journal Prostate
Print ISSN 0270-4137
Electronic ISSN 1097-0045
Publisher Wiley Open Access
Peer Reviewed Peer Reviewed
Volume 79
Issue 5
Pages 462-467
DOI https://doi.org/10.1002/pros.23752
Keywords Prostatectomy; Selenium; Selenoproteins
Public URL http://hdl.handle.net/10059/3307

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