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Patients' lived experiences with antineoplastic medicines for the management of malignant solid tumours: a systematic review.

Brincat, Alison; Bonanno, Patricia Vella; Stewart, Derek; Weidmann, Anita E.

Authors

Alison Brincat

Patricia Vella Bonanno

Derek Stewart

Anita E. Weidmann



Abstract

Background: Antineoplastic medicines affect the patients’ physical and psychosocial well-being posing challenges for patients, caregivers and healthcare professionals. However, little is known about the patients’ lived experience with medicines (PLEM) for antineoplastic treatment. It is the lived experience that gives meaning to each individual’s perception of a particular phenomenon which is influenced by internal and external factors relevant to the individual. Objectives: To critically appraise, synthesise and present the available evidence of patients’ lived experience with antineoplastic medicines prescribed for the management of malignant solid tumours. Method: A systematic literature search was conducted in six electronic databases for articles published in English with no date restrictions. The search terms were related to beliefs, practice and burden in relation to patient, antineoplastic medicines, tumours and lived experience. Study selection, quality assessment and data extraction were performed independently by 2 reviewers. Research findings were analysed using narrative and meta-synthesis approaches. Results: The search retrieved 31,004 articles with only 10 studies satisfying the inclusion and exclusion criteria. These studies were published between 2005 and 2016 in Europe (n=6), America (n=3) and Asia (n=1). Nine themes were identified to contribute to the patients’ lived experience with antineoplastic medicines. These were (a) influence from family members, healthcare professionals, media and culture, (b) general attitude towards medicine, (c) accepting medicine, (d) modifying or altering medicine regimen or dose, (e) medicine characteristics, (f) medicine routine, (g) medicine adverse events, (h) medicine and social burden and (i) healthcare associated medicine burden. Patients tend to undergo a continuous process of reinterpretations of their experience with medicines throughout their treatment journey. Conclusion: The use of antineoplastic medicines has a profound effect on the patients’ lives. Further longitudinal in-depth studies are required to provide deeper insight into PLEM and support patients in their treatment journey.

Journal Article Type Article
Publication Date 2019-06
Journal Research in social and administrative pharmacy
Print ISSN 1551-7411
Electronic ISSN 1934-8150
Publisher Elsevier
Peer Reviewed Peer Reviewed
Institution Citation BRINCAT, A., BONANNO, P.V., STEWART, D. and WEIDMANN, A.E. 2019. Patients’ lived experiences with antineoplastic medicines for the management of malignant solid tumours: a systematic review. Research in social and administrative pharmacy [online], In Press. Available from: https://doi.org/10.1016/j.sapharm.2019.06.020
DOI https://doi.org/10.1016/j.sapharm.2019.06.020
Keywords Solid tumor; Antineoplastic medicines; Patients’ lived experience with medicine; Medicine-taking practice; Medicine-related beliefs; Medicine-related burden
Related Public URLs http://hdl.handle.net/10059/3084

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