Research Repository

See what's under the surface

Raman spectroscopy vs voltammetry: a voltammetric approach to elucidate different chemicals in a range of pharmaceutical tablets.

Alecrim, M. F.; Macêdo, I. Y. L.; Rodrigues, E. B.; Moreno, E. K. G.; Ghedini, P. C.; Fernandez, C.; Dos Santos, W. T. P.; Gil, E. S.

Authors

M. F. Alecrim

I. Y. L. Macêdo

E. B. Rodrigues

E. K. G. Moreno

P. C. Ghedini

C. Fernandez

W. T. P. Dos Santos

E. S. Gil

Abstract

Over the years, Electroanalysis has been widely applied to elucidate redox behavior of novel molecules. The selectivity and low cost are spotlight features in pharmacopeial methods of identification, that can be reached by voltammetric approaches. In this work, differential pulse voltammetric (DPV) profile and the slope of the linear regression obtained from calibration graphs along with the scan study are proposed as new perspective of identification assays. With the proposed methodology we were able to identify the similarities among DPV profile and the slopes obtained for each tablet. In addition, this new technology was successfully employed to identify the following chemicals: Paracetamol (PAR), Promethazine (PMZ), Diclofenac (DIC), Piroxicam (PRX), Indomethacin (IND) and Cyclobenzaprine (CBP) in pharmaceutical assays using Pencil Graphite Electrodes. Furthermore, our new methodology was effectively compared to Raman Spectroscopy for the analysis of the range of chemicals in the pharmaceutical assays.

Journal Article Type Article
Publication Date Aug 31, 2019
Journal Journal of The Electrochemical Society
Print ISSN 0013-4651
Electronic ISSN 1945-7111
Publisher Electrochemical Society
Peer Reviewed Peer Reviewed
Volume 166
Issue 12
Pages H580-H586
Institution Citation ALECRIM, M.F., MACÊDO, I.Y.L., RODRIGUES, E.B., MORENO, E.K.G., GHEDINI, P.C., FERNANDEZ, C., DOS SANTOS, W.T.P. and GIL, E.S. 2019. Raman spectroscopy vs voltammetry: a voltammetric approach to elucidate different chemicals in a range of pharmaceutical tablets. Journal of the Electrochemical Society [online], 166(12), pages H580-H586. Available from: https://doi.org/10.1149/2.1331912jes
DOI https://doi.org/10.1149/2.1331912jes
Keywords Electroanalytical electrochemistry; Electrocatalysis; Sensors; Differential pulse voltammetry; Pharmaceutical analysis; Raman spectroscopy

Files




Downloadable Citations