Meta-analysis demonstrates Gly482Ser variant of PPARGC1A is associated with components of metabolic syndrome within Asian populations.
Bhatta, Prabhakar; Bermano, Giovanna; Williams, Hector C.; Knott, Rachel M.
Professor Giovanna Bermano email@example.com
Hector C. Williams
Rachel M. Knott
To determine the association of peroxisome proliferator activated receptor gamma coactivator 1 Gly482Ser variant with components of metabolic syndrome. Materials and methods:- A systematic search was carried out using Web of Science, PubMed, EMBASE and the Cochrane library using the key words: Peroxisome proliferator activator receptor gamma coactivator 1, PPARGC1A, PGC-1, PGC-1alpha, and PGC1alpha alone or with polymorphism, Gly482Ser and rs8192678. Results:- Data from 19 articles generated 28 separate data sets. Under the recessive model fasting plasma glucose was significantly lower in AA genotypes when compared to GG+GA in the total sample group and in non-Asian group (p[less than].001). The AA genotype showed significantly lower levels of total cholesterol compared to GG+GA genotype using the recessive model with the non-Asian group (p[less than].05). Under the dominant model, body mass index of the GG genotype was significantly higher in Asian subgroups (p[less than].05). Conclusion:- PPARGC1A Gly482Ser variant impacts differently in Asian population groups.
BHATTA, P., BERMANO, G., WILLIAMS, H.C. and KNOTT, R.M. 2020. Meta-analysis demonstrates Gly482Ser variant of PPARGC1A is associated with components of metabolic syndrome within Asian populations. Genomics [online], 112(2), pages 1795-1803. Available from: https://doi.org/10.1016/j.ygeno.2019.10.011
|Journal Article Type||Article|
|Acceptance Date||Oct 17, 2019|
|Online Publication Date||Oct 31, 2019|
|Publication Date||Mar 31, 2020|
|Deposit Date||Nov 1, 2019|
|Publicly Available Date||Nov 1, 2020|
|Peer Reviewed||Peer Reviewed|
|Keywords||Metabolic syndrome; PPARGC1?; Meta-analysis; Gly482Ser; Single nucleotide polymorphism|
BHATTA 2020 Meta analysis
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