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Meta-analysis demonstrates Gly482Ser variant of PPARGC1A is associated with components of metabolic syndrome within Asian populations.

Bhatta, Prabhakar; Bermano, Giovanna; Williams, Hector C.; Knott, Rachel M.

Authors

Prabhakar Bhatta

Hector C. Williams

Rachel M. Knott



Abstract

To determine the association of peroxisome proliferator activated receptor gamma coactivator 1 Gly482Ser variant with components of metabolic syndrome. Materials and methods:- A systematic search was carried out using Web of Science, PubMed, EMBASE and the Cochrane library using the key words: Peroxisome proliferator activator receptor gamma coactivator 1, PPARGC1A, PGC-1, PGC-1alpha, and PGC1alpha alone or with polymorphism, Gly482Ser and rs8192678. Results:- Data from 19 articles generated 28 separate data sets. Under the recessive model fasting plasma glucose was significantly lower in AA genotypes when compared to GG+GA in the total sample group and in non-Asian group (p[less than].001). The AA genotype showed significantly lower levels of total cholesterol compared to GG+GA genotype using the recessive model with the non-Asian group (p[less than].05). Under the dominant model, body mass index of the GG genotype was significantly higher in Asian subgroups (p[less than].05). Conclusion:- PPARGC1A Gly482Ser variant impacts differently in Asian population groups.

Citation

BHATTA, P., BERMANO, G., WILLIAMS, H.C. and KNOTT, R.M. 2020. Meta-analysis demonstrates Gly482Ser variant of PPARGC1A is associated with components of metabolic syndrome within Asian populations. Genomics [online], 112(2), pages 1795-1803. Available from: https://doi.org/10.1016/j.ygeno.2019.10.011

Journal Article Type Article
Acceptance Date Oct 17, 2019
Online Publication Date Oct 31, 2019
Publication Date Mar 31, 2020
Deposit Date Nov 1, 2019
Publicly Available Date Nov 1, 2020
Journal Genomics
Print ISSN 0888-7543
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 112
Issue 2
Pages 1795-1803
DOI https://doi.org/10.1016/j.ygeno.2019.10.011
Keywords Metabolic syndrome; PPARGC1Α; Meta-analysis; Gly482Ser; Single nucleotide polymorphism
Public URL https://rgu-repository.worktribe.com/output/730349

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