Meta-analysis demonstrates Gly482Ser variant of PPARGC1A is associated with components of metabolic syndrome within Asian populations.

Bhatta, Prabhakar; Bermano, Giovanna; Williams, Hector C.; Knott, Rachel M.

Abstract

To determine the association of peroxisome proliferator activated receptor gamma coactivator 1 Gly482Ser variant with components of metabolic syndrome. Materials and methods:- A systematic search was carried out using Web of Science, PubMed, EMBASE and the Cochrane library using the key words: Peroxisome proliferator activator receptor gamma coactivator 1, PPARGC1A, PGC-1, PGC-1alpha, and PGC1alpha alone or with polymorphism, Gly482Ser and rs8192678. Results:- Data from 19 articles generated 28 separate data sets. Under the recessive model fasting plasma glucose was significantly lower in AA genotypes when compared to GG+GA in the total sample group and in non-Asian group (p[less than].001). The AA genotype showed significantly lower levels of total cholesterol compared to GG+GA genotype using the recessive model with the non-Asian group (p[less than].05). Under the dominant model, body mass index of the GG genotype was significantly higher in Asian subgroups (p[less than].05). Conclusion:- PPARGC1A Gly482Ser variant impacts differently in Asian population groups.

Citation

BHATTA, P., BERMANO, G., WILLIAMS, H.C. and KNOTT, R.M. 2020. Meta-analysis demonstrates Gly482Ser variant of PPARGC1A is associated with components of metabolic syndrome within Asian populations. Genomics [online], 112(2), pages 1795-1803. Available from: https://doi.org/10.1016/j.ygeno.2019.10.011

• Journal Article Type: Article
• Acceptance Date: Oct 17, 2019
• Online Publication Date: Oct 31, 2019
• Publication Date: Mar 31, 2020
• Deposit Date: Nov 1, 2019
• Publicly Available Date: Nov 1, 2020
• Journal: Genomics
• Print ISSN: 0888-7543
• Electronic ISSN: 1089-8646
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 112
• Issue: 2
• Pages: 1795-1803
• DOI: https://doi.org/10.1016/j.ygeno.2019.10.011
• Keywords: Metabolic syndrome; PPARGC1Α; Meta-analysis; Gly482Ser; Single nucleotide polymorphism
• Public URL: https://rgu-repository.worktribe.com/output/730349