Anti-pancreatic cancer potential of secalonic acid derivatives from endophytic fungi isolated from Ocimum basilicum.

Shoeb, M.; Hoque, M.E.; Kong Thoo Lin, P.; Nahar, N.

Abstract

The word endophyte means "in the plant" and refers to all microorganisms that live in the intercellular spaces of stems, petioles, roots and leaves of plants causing no apparent symptoms of disease. Seven endophytic fungi were isolated from the medicinal plant of Ocimum basilicum L. The fungal strain, labeled as 2L, was cultivated at large scale on the potato dextrose agar semi solid medium and was extracted with ethyl acetate. Normal phase silica gel column chromatography of the ethyl acetate extract afforded ergosterol (1), secalonic acid A (2) and secalonic acid D (3). The structures of these compounds (1-3) were elucidated unequivocally by UV, IR, MS, a series of 1D & 2D NMR analyses. The cytotoxicity of these compounds was evaluated by the MTT assay against human pancreatic cancer cell line. Secalonic acid A (2) and secalonic acid D (3) exhibited significant anti-pancreatic cancer activity with IC 50 values of 7.3 and 1.6 µM, respectively.

Citation

SHOEB, M., HOQUE, M.E., KONG THOO LIN, P. and NAHAR, N. 2013. Anti-pancreatic cancer potential of secalonic acid derivatives from endophytic fungi isolated from Ocimum basilicum. Dhaka University journal of pharmaceutical sciences [online], 12(2), pages 91-95. Available from: https://doi.org/10.3329/dujps.v12i2.17624

• Journal Article Type: Article
• Acceptance Date: Dec 31, 2013
• Online Publication Date: Jan 12, 2014
• Publication Date: Dec 31, 2013
• Deposit Date: Aug 23, 2022
• Publicly Available Date: Aug 25, 2022
• Journal: Dhaka University journal of pharmaceutical sciences
• Print ISSN: 1816-1820
• Electronic ISSN: 1816-1839
• Publisher: University of Dhaka. Faculty of Pharmacy
• Peer Reviewed: Peer Reviewed
• Volume: 12
• Issue: 2
• Pages: 91-95
• DOI: https://doi.org/10.3329/dujps.v12i2.17624
• Keywords: Endophytic fungi; Secalonic acida A and D; Ergosterol; Pancreatic cancer
• Public URL: https://rgu-repository.worktribe.com/output/865396