All Outputs (12)

Development, characterisation and neuroprotective effects of polymer-drug conjugate nano-polyplex: working towards a multi-target treatment for neurodegenerative diseases. (2025)
Journal Article
MAHADIK, N., BARRON, G.A., KONG THOO LIN, P. and THOMPSON, C.J. 2025. Development, characterisation and neuroprotective effects of polymer-drug conjugate nano-polyplex: working towards a multi-target treatment for neurodegenerative diseases. Materials advances [online], 6(13), pages 4438-4455. Available from: https://doi.org/10.1039/D5MA00174A

Neurodegenerative diseases (NDs) are complex, multifaceted conditions that require novel, multi-targeted therapeutic approaches. This study aimed to develop a multifunctional polymer-drug conjugate (PDC) by employing a novel strategy of utilizing PDC... Read More about Development, characterisation and neuroprotective effects of polymer-drug conjugate nano-polyplex: working towards a multi-target treatment for neurodegenerative diseases..

Synthesis and evaluation of polymer-drug conjugates as potential antioxidant and cholinesterase inhibitors for neurodegenerative diseases. (2024)
Journal Article
MAHADIK, N., BARRON, G., KONG THOO LIN, P. and THOMPSON, C. 2024. Synthesis and evaluation of polymer-drug conjugates as potential antioxidant and cholinesterase inhibitors for neurodegenerative diseases. Chemistry of materials [online], 36(21), pages 10514-10527. Available from: https://doi.org/10.1021/acs.chemmater.4c01767

Polymer-drug conjugates (PDCs) may offer improved water-solubility and in vitro activity of potential antioxidant and cholinesterase (ChE) inhibitor drugs compared to the drugs alone. Conjugation of these potential drugs to water-soluble polymers cou... Read More about Synthesis and evaluation of polymer-drug conjugates as potential antioxidant and cholinesterase inhibitors for neurodegenerative diseases..

Polymer-drug conjugates as nano-sized multi-targeting systems for the treatment of Alzheimer's disease. (2024)
Journal Article
MAHADIK, N., BARRON, G.A., KONG THOO LIN, P. and THOMPSON, C.J. 2024. Polymer-drug conjugates as nano-sized multi-targeting systems for the treatment of Alzheimer's disease. RSC pharmaceutics [online], 1(2), pages 161-181. Available from: https://doi.org/10.1039/D3PM00075C

Alzheimer's disease (AD) is a progressive, neurodegenerative condition. There are clear markers for the presence and progression of the disease, including β-amyloid (Aβ) plaques and Tau tangles, with many potential causes debated in the scientific co... Read More about Polymer-drug conjugates as nano-sized multi-targeting systems for the treatment of Alzheimer's disease..

Spore exines increase vitamin D clinical bioavailability by mucoadhesion and bile triggered release. (2022)
Journal Article
DIEGO-TABOADA, A., SATHYAPALAN, T., COURTS, F., LORCH, M., ALMUTAIRI, F., BURKE, B.P., HARRIS, K., KRUUSMÄGI, M., WALTHER, T., BOOTH, J., BOA, A.N., ARCHIBALD, S.J., THOMPSON, C., ATKIN, S.L. and MACKENZIE, G. 2022. Spore exines increase vitamin D clinical bioavailability by mucoadhesion and bile triggered release. Journal of controlled release [online], 350, pages 244-255. Available from: https://doi.org/10.1016/j.jconrel.2022.08.017

Sporopollenin exine capsules (SpECs) are microcapsules derived from the outer shells (exines) of plant spore and pollen grains. This work reports the first clinical study on healthy volunteers to show enhanced bioavailability of vitamin D encapsulate... Read More about Spore exines increase vitamin D clinical bioavailability by mucoadhesion and bile triggered release..

Spore exines increase vitamin D clinical bioavailability by mucoadhesion and bile triggered release. [Dataset] (2022)
Data
DIEGO-TABOADA, A., SATHYAPALAN, T., COURTS, F., LORCH, M., ALMUTAIRI, F., BURKE, B.P., HARRIS, K., KRUUSMÄGI, M., WALTHER, T., BOOTH, J., BOA, A.N., ARCHIBALD, S.J., THOMPSON, C., ATKIN, S.L. and MACKENZIE, G. 2022. Spore exines increase vitamin D clinical bioavailability by mucoadhesion and bile triggered release. [Dataset] Journal of controlled release [online], 350, pages 244-255. Available from: https://www.sciencedirect.com/science/article/pii/S0168365922005211?via%3Dihub#s0180

Sporopollenin exine capsules (SpECs) are microcapsules derived from the outer shells (exines) of plant spore and pollen grains. This work reports the first clinical study on healthy volunteers to show enhanced bioavailability of vitamin D encapsulate... Read More about Spore exines increase vitamin D clinical bioavailability by mucoadhesion and bile triggered release. [Dataset].

Novel nanoparticle drug delivery systems: application in the in vitro study of Bisnaphthalimidopropyl derivatives against human colorectal cancer cell lines. (2021)
Thesis
BRUNET, M. 2021. Novel nanoparticle drug delivery systems: application in the in vitro study of Bisnaphthalimidopropyl derivatives against human colorectal cancer cell lines. Robert Gordon University, MRes thesis. Hosted on OpenAIR [online]. Available from: https://doi.org/10.48526/rgu-wt-1446968

Colorectal cancer is one of the most severe causes of mortality worldwide accounting for 10% of total cancer cases. Although recent advances in early diagnosis have reduced the mortality rate associated with CRC, patients suffering from the later met... Read More about Novel nanoparticle drug delivery systems: application in the in vitro study of Bisnaphthalimidopropyl derivatives against human colorectal cancer cell lines..

Complexation of novel thiomers and insulin to protect against in vitro enzymatic degradation: towards oral insulin delivery. (2018)
Journal Article
IBIE, C.O., KNOTT, R.M. and THOMPSON, C.J. 2019. Complexation of novel thiomers and insulin to protect against in vitro enzymatic degradation: towards oral insulin delivery. Drug development and industrial pharmacy [online], 45(1), pages 67-75. Available from: https://doi.org/10.1080/03639045.2018.1517776

A significant barrier to oral insulin delivery is its enzymatic degradation in the gut. Nano-sized polymer-insulin polyelectrolyte complexes (PECS) have been developed to protect insulin against enzymatic degradation. Poly(allylamine) (Paa) was trime... Read More about Complexation of novel thiomers and insulin to protect against in vitro enzymatic degradation: towards oral insulin delivery..

A novel polyelectrolyte complex between amphiphilic poly (allyl amine) and sodium alginate. (2015)
Thesis
SARTAWI, Z. 2015. A novel polyelectrolyte complex between amphiphilic poly (allyl amine) and sodium alginate. Robert Gordon University, MRes Thesis.

Polyelectrolytes are charge-carrying polymers. When two oppositely-charged polyelectrolytes are combined in a solution favouring charge expression, a polyelectrolyte complex can result. These complexes have been shown to be useful in the field of dru... Read More about A novel polyelectrolyte complex between amphiphilic poly (allyl amine) and sodium alginate..

Synthesis, characterisation and in vitro evaluation of novel thiolated derivatives of polyallylamine and quaternised polyallylamine. (2015)
Journal Article
IBIE, C.O., THOMPSON, C.J. and KNOTT, R. 2015. Synthesis, characterisation and in vitro evaluation of novel thiolated derivatives of polyallylamine and quaternised polyallylamine. Colloid and polymer science [online], 293(6), pages 1737-1748. Available from: https://doi.org/10.1007/s00396-015-3561-4

Polyallylamine (Paa) was quaternised by methylation of its primary amines using methyl iodide to yield quaternised Paa (QPaa). Average level of polymer quaternisation was determined by elemental analysis and was found to be 72 ± 2mol%. Subsequent thi... Read More about Synthesis, characterisation and in vitro evaluation of novel thiolated derivatives of polyallylamine and quaternised polyallylamine..

In-vitro evaluation of the effect of polymer structure on uptake of novel polymer-insulin polyelectrolyte complexes by human epithelial cells. (2014)
Journal Article
IBIE, C., KNOTT, R. and THOMPSON, C.J. 2015. In-vitro evaluation of the effect of polymer structure on uptake of novel polymer-insulin polyelectrolyte complexes by human epithelial cells. International journal of pharmaceutics [online], 479(1), pages 103-117. Available from: https://doi.org/10.1016/j.ijpharm.2014.12.058

The biocompatibility and cellular uptake of polymer, insulin polyelectrolyte complexes (PECs) prepared using polyallylamine-based polymers was evaluated in-vitro using Caco-2 cell monolayers as a predictive model for human small intestinal epithelial... Read More about In-vitro evaluation of the effect of polymer structure on uptake of novel polymer-insulin polyelectrolyte complexes by human epithelial cells..

Novel polyelectrolyte complexes for oral insulin delivery. (2013)
Thesis
IBIE, C.O. 2013. Novel polyelectrolyte complexes for oral insulin delivery. Robert Gordon University, PhD thesis.

Oral delivery of insulin used for the management of Type 1 diabetes could be referred to as one of the major long-term goals of diabetes research. However, the bioavailability of orally-administrered insulin is significantly compromised by enzymatic... Read More about Novel polyelectrolyte complexes for oral insulin delivery..

In vitro and in vivo characterisation of a novel peptide delivery system: amphiphilic polyelectrolyte–salmon calcitonin nanocomplexes. (2010)
Journal Article
CHENG, W.-P., THOMPSON, C., RYAN, S.M., AGUIRRE, T., TETLEY, L. and BRAYDEN, D.J. 2010. In vitro and in vivo characterisation of a novel peptide delivery system: amphiphilic polyelectrolyte–salmon calcitonin nanocomplexes. Journal of controlled release [online], 147(2), pages 289-297. Available from: https://doi.org/10.1016/j.jconrel.2010.07.128

The cationic peptide, salmon calcitonin (sCT) was complexed with the cationic amphiphilic polyelectrolyte, poly(allyl)amine, grafted with palmitoyl and quaternary ammonium moieties at pH 5.0 and 7.4 to yield particulates (sCT-QPa). The complexes were... Read More about In vitro and in vivo characterisation of a novel peptide delivery system: amphiphilic polyelectrolyte–salmon calcitonin nanocomplexes..