All Outputs (52)

Leptin inhibits proliferation of breast cancer cells at supraphysiological concentrations by inhibiting mitogen-activated protein kinase signaling. (2014)
Journal Article
WEICHHAUS, M., BROOM, J., WAHLE, K. and BERMANO, G. 2014. Leptin inhibits proliferation of breast cancer cells at supraphysiological concentrations by inhibiting mitogen-activated protein kinase signaling. Oncology letters [online], 8(1), pages 374-378. Available from: https://doi.org/10.3892/ol.2014.2085

Leptin is a hormone secreted by white fat tissue and signals the amount of overall body fat to the hypothalamus. The circulating concentration of leptin correlates with the level of obesity. Breast cancer risk is higher in obese postmenopausal women... Read More about Leptin inhibits proliferation of breast cancer cells at supraphysiological concentrations by inhibiting mitogen-activated protein kinase signaling..

Impact of high intensity interval training (HIIT) and/or selenium (Se) supplementation on oxidative stress and antioxidant status in active females. (2014)
Thesis
KEANE, K. 2014. Impact of high intensity interval training (HIIT) and/or selenium (Se) supplementation on oxidative stress and antioxidant status in active females. Robert Gordon University, MRes thesis.

Background: Cells continuously produce free radicals (FR) and reactive oxygen species (ROS) as part of metabolic processes. These free radicals are neutralized by an elaborate antioxidant defence system consisting of enzymes. An imbalance between ROS... Read More about Impact of high intensity interval training (HIIT) and/or selenium (Se) supplementation on oxidative stress and antioxidant status in active females..

Control of surface interactions with ultra-violet/ozone modification at polystyrene surface. (2014)
Thesis
LIANG, H. 2014. Control of surface interactions with ultra-violet/ozone modification at polystyrene surface. Robert Gordon University, PhD thesis.

Surface interactions and reactivity are of critical importance in current biomedical technologies, for example, satisfactory cell attachment and long term viability are essential for optimal in vitro tissue culture and for successful implantation and... Read More about Control of surface interactions with ultra-violet/ozone modification at polystyrene surface..

Obesity and its health impact in Africa: a systematic review. (2012)
Journal Article
ADEBOYE, B., BERMANO, G. and ROLLAND, C., 2012. Obesity and its health impact in Africa: a systematic review. Cardiovascular journal of Africa [online], 23(9), pp. 512-521. Available from: https://doi.org/10.5830/CVJA-2012-040

Obesity and its association with co-morbidities in Africa are on the rise. This systematic review examines evidence of obesity and its association with co-morbidities within the African continent. Comparative studies conducted in Africa on adults 17... Read More about Obesity and its health impact in Africa: a systematic review..

The molecular contribution of TNF-α in the link between obesity and breast cancer. (2010)
Journal Article
WEICHHAUS, M., BROOM, I. and BERMANO, G. 2011. The molecular contribution of TNF-α in the link between obesity and breast cancer. Oncology reports [online], 25(2), pages 477-483. Available from: https://doi.org/10.3892/or.2010.1099

Obesity is a growing worldwide medical problem, as it pre-disposes the affected hosts to a number of severe diseases, including postmenopausal breast cancer. Obesity development is characterised, amongst others, by aberrant secretion of adipokines. W... Read More about The molecular contribution of TNF-α in the link between obesity and breast cancer..

Molecular aspects of the link between obesity, insulin resistance and breast cancer. (2010)
Thesis
WEICHHAUS, M.G. 2010. Molecular aspects of the link between obesity, insulin resistance and breast cancer. Robert Gordon University, PhD thesis.

Obesity is a multi-factorial metabolic disease, resulting in increased adipose tissue acquisition by the host. This disease increases the risk for developing co-morbidities, including Metabolic Syndrome and other disorders such as breast cancer. Obes... Read More about Molecular aspects of the link between obesity, insulin resistance and breast cancer..

Novel bisnaphthalimidopropyl polyamine derivatives: their mode of action in a breast cancer cell system. (2010)
Thesis
BARRON, G. 2010. Novel bisnaphthalimidopropyl polyamine derivatives: their mode of action in a breast cancer cell system. Robert Gordon University, PhD thesis.

The synthesis and characterisation of novel bisnaphthalimidopropyl polyamine (BNIPP) derivatives has gained pace over the last couple of years, as they have enhanced aqueous solubility without loss of biological activity in contrast to parent bisnaph... Read More about Novel bisnaphthalimidopropyl polyamine derivatives: their mode of action in a breast cancer cell system..

Insulin-induced gene expression changes in breast cancer cells and normal breast epithelial cells. (2009)
Presentation / Conference Contribution
WEICHHAUS, M., BROOM, J., WAHLE, K., HEYS, S. and BERMANO, G. 2009. Insulin-induced gene expression changes in breast cancer cells and normal breast epithelial cells. Presented at 17th European congress on obesity 2009 (ECO 2009), 6-9 May 2009, Amsterdam, Netherlands.

Obesity increases breast cancer incidence rates in postmenopausal women. Chronic high levels of insulin, present in the majority of obese and insulin resistant patients, may provide the growth promoting stimulus to explain this connection. In this wo... Read More about Insulin-induced gene expression changes in breast cancer cells and normal breast epithelial cells..

Molecular aspects linking insulin resistance to breast cancer by activation of cell signalling pathways. (2008)
Presentation / Conference Contribution
WEICHHAUS, M., BROOM, J., WAHLE, K. and BERMANO, G. 2008. Molecular aspects linking insulin resistance to breast cancer by activation of cell signalling pathways. Presented at 6th annual World congress on insulin resistance syndrome 2008 (WCIRS 2008), 25-27 September 2008, Los Angeles, U.S.A.

Recent findings suggest a connection between obesity and breast cancer. Obesity is linked with higher incidences of insulin resistance as part of the metabolic syndrome, resulting in chronically elevated insulin plasma levels. We examined the effect... Read More about Molecular aspects linking insulin resistance to breast cancer by activation of cell signalling pathways..

Molecular aspects of insulin resistance, cell signaling pathways and breast cancer in relation to obesity. (2008)
Presentation / Conference Contribution
WEICHHAUS, M., BROOM, J., WAHLE, K. and BERMANO, G. 2008. Molecular aspects of insulin resistance, cell signaling pathways and breast cancer in relation to obesity. Presented at 16th European congress on obesity 2008 (ECO 2008), 14-17 May 2008, Geneva, Switzerland.

A growing number of clinical studies validate a relation of insulin resistance and breast cancer in obese patients. We hypothesised that high plasma insulin levels cause aberrant insulin signalling in breast epithelial cells which may be responsible... Read More about Molecular aspects of insulin resistance, cell signaling pathways and breast cancer in relation to obesity..

Selenoprotein gene expression in an intestinal cell line during selenium depletion: a macroarray approach indicates effects on SelW and glutathione peroxidise 1. (2003)
Presentation / Conference Contribution
PAGMANTIDIS, V., VILLETTE, S., BERMANO, G., BROOM, J., ARTHUR, J.R. and HESKETH, J.E. 2003. Selenoprotein gene expression in an intestinal cell line during selenium depletion: a macroarray approach indicates effects on SelW and glutathione peroxidise 1. Proceedings of the Nutrition Society [online], 62(1A), page 72A. Available from: https://doi.org/10.1017/S0029665103000776

The micronutrient selenium (Se) is incoprprated into a renage of selenoproteins involved in numerous biochemical processes within the body.

Selenoprotein expression in the rat colon during Se deficiency. (2002)
Presentation / Conference Contribution
PAGMANTIDIS, V., BERMANO, G., BROOM, J., ARTHUR, J.R. and HESKETH, J.E. 2002. Selenoprotein expression in the rat colon during Se deficiency. Proceedings of the Nutrition Society [online], 61(2A), page 51A. Available from: https://doi.org/10.1017/S0029665102000228

Selenium is an essential trace element, which is present in several proteins, called seleneproteins, that have various biological roles.